Evaluation of the Effects of 0.03% Tacrolimus on Schirmer Tear Test and Tear Film Break-Up Time in Patients of Chronic Dry Eye Disease
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 2
Abstract
Introduction: The aim of this study was to evaluate the effects of 0.03% tacrolimus on Schirmer tear test and tearfilm breakup time in patients with chronic dry eye disease. Material and Methods: This was a single centred, open label, 3 months prospective study. Patients with unilateral or bilateral dry eye disease and an ocular surface disease index score >12, atleast one eye with schirmer score <5mm and TBUT <10 s were enrolled in the study. Tacrolimus 0.03% eye ointment was instilled twice daily for three months in the affected eye.The primary efficacy outcome was Schirmer score after 3 months. The secondary outcomes were TBUT, OSDI score and adverse events. Results: A total of 30 patients with the mean age of 51.92 ± 8.86 were enrolled and 25 patients completed the study. After 3 months significant improvement was seen in schirmer tear test (P<0.001), 44% patients showed ≥ 5 mm improvement and 12% patients showed ≥ 10 mm improvement in Schirmer score. Mean tear film breakup time also showed significant improvement after 3 months (p <0.001).Patients also reported significant improvement in ocular discomfort and dry eye symptoms suggested by decrease in OSDI score (p < 0.001). No patients discontinued treatment because of mild burning or irritation or any other ocular adverse event. Conclusion: Dry eye patients demonstrated improvement in both signs and symptoms of dry eye after 3 months of treatment with 0.03% tacrolimus ointment.
Authors and Affiliations
Zeenat Fatima, Rakesh C. Chaurasia, Satya Prakash Singh
Keywords
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