EVALUATION OF THE EFFECTS OF CAPSULES CONTAINING TRIBULUS TERRESTRIS EXTRACT AND LCARNITINE ON TREATMENT OF OLIGOSPERMIA IN MALES
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 29
Abstract
BACKGROUND Infertility is defined as failure to achieve pregnancy after one year of unprotected sexual intercourse. Male infertility is one of the most challenging problems in andrology. The common cause of male infertility is related to disorders in sperm production. In this study for the first time, effect of combination Tribulus terrestris extract and L-carnitine on sperm parameters of infertile men were reviewed. MATERIALS AND METHODS This double-blind study was conducted on 61 men, 25 to 40 years old with infertility due to sperm abnormalities on semen analysis parameters (Criteria WHO). They were randomly assigned to two groups of 350 mg herbal capsules containing Tribulus terrestris extract + L-carnitine (Intervention) or 350 mg placebo capsules (Control) 4 times a day for 3 months. At the beginning and end of the study, semen analysis and serum levels of FSH, LH and testosterone were evaluated, and results were compared between the groups with baseline. RESULTS The results showed that after three months of intervention in control group, no significant change in semen analysis parameters and levels of FSH, LH and testosterone happened (p>0.5). In the intervention group, only Progressive index in semen analysis (28.6 vs 33.2) from baseline showed statistically significant changes (p=0.033). The difference of efficacy between intervention and control groups before and after the study was not significant in any of the parameters. CONCLUSION Based on the results of this study, treatment with herbal capsule containing Tribulus terrestris extract and L-carnitine for three months in the improvement of abnormal sperm parameters in infertile men is not effective.
Authors and Affiliations
Mahmoudi Hossein, Akbari Hossein, Taghizade Mohsen, Jahangirian Jamileh, Mohboobi Mohadese, Mahlooji Mahnaz
Keywords
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- EP ID EP538307
- DOI 10.14260/jemds/2018/736
- Views 76
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