Evaluation of the fertility activity of the aqueous leaves extract of Zanthoxylum macrophylla (Rutaceae) on male rats
Journal Title: The Journal of Phytopharmacology - Year 2017, Vol 6, Issue 5
Abstract
Zanthoxylum macrophylla, one of the useful medicinal plants in Cameroon, was scientifically conducted to find its aqueous extract leaves effect in some fertility parameters of male rats. 24 rats were randomly divided into 4 groups: Control, A, B and C group of six animals each. They received respectively 0, 100, 200 and 400 mg/kg body weight of aqueous extract of Z. macrophylla leaves on daily basis for 14 days. There were no significant changes on the body weight of treated animals. However, the weight of testis and the Daily Sperm Production respectively increased at dose of 200 mg/kg (P< 0.05 and P< 0.001) and 400 mg/kg (P< 0.01 and P< 0.001) while the weight of seminal vesicle and prostate also increased respectively at dose of 200 mg/kg (P< 0.05) and 400 mg/kg (P< 0.01) when compared to the control. The serum testosterone level significantly increased at the dose of 200 mg/kg (P< 0.01) and 400 mg/kg (P< 0.001) while the total cholesterol decreased at dose of 400 mg/kg (P< 0.05) when compared to the control. The serum protein decreased respectively at dose of 200 mg/kg (P< 0.01) and 400 mg/kg (P< 0.01) when compared to the control. The histological sections of the testis did not show any structural abnormalities in all treated animals. These results indicate that Zanthoxylum macrophylla could improve male reproductive activities.
Authors and Affiliations
Ngandjui Alphonse, Ngaha Njila Marie, Kenmogne Hubert, Koloko Brice Landry, Massoma Lembe Dieudonné, Bend Emma Fortune, Oundoum Oudoum Pierre, Domkam Judith, Moundipa Paul, Dimo Théophile
Keywords
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