EVALUATION OF THE POSSIBLE RENOPROTECTIVE EFFECT AND ANTIOXIDANT ACTIVITY OF MIRABEGRON ON GENTAMICIN-INDUCED NEPHROTOXICITY IN RATS
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2019, Vol 6, Issue 3
Abstract
Introduction: Mirabegron is a novel β3-adrenergic receptor agonist that recently approved for the management of overactive urinary bladder disease. Reactive oxygen species (ROS) have a major role in the pathogenesis of gentamicin nephrotoxicity. The aim of the present study was to investigate the renoprotective effect of mirabegron alone and in combination with N-acetylcysteine (NAC) in cases of nephrotoxicity induced by gentamicin in rats. Materials and Methods: 40 Wistar rats were divided into 5 groups. Group 1; treated with NaCl 0.2 ml i.p. Group 2; received 100 mg/kg of gentamicin i.p. for 8 days for induction of nephrotoxicity. Group 3; treated with gentamicin + NAC (500 mg/kg i.p.for 8 days). Group 4; treated with gentamicin + mirabegron (10 mg/kg orally for 8 days). Group 5; treated with gentamicin + NAC + mirabegron. After 8 days, blood samples were used for assessment of renal function. Serum nitric oxide, renal malondialdehyde (MDA) and glutathione (GSH) levels were measured. Results: Gentamicin caused a significant elevation of serum creatinine, urea, uric acid and nitric oxide with significant elevation of kidney MDA with reduction of GSH. Treatment with both of NAC and mirabegron each alone or in combination with each other caused restoration of renal function parameters and caused significant decrease in serum nitric oxide and MAD and increase in GSH. These changes were more marked with combination of NAC and mirabegron. Conclusion: Mirabegron has a modest antioxidant activity which may be responsible for its protective effect against nephrotoxicity induced by gentamicin.
Authors and Affiliations
Dr. Mohamed Mostafa Elbadr
Keywords
Related Articles
- EP ID EP670540
- DOI -
- Views 125
- Downloads 0
THE RELATIONSHIP BETWEEN SOMATOTYPE AND BLOOD PRESSURE AMONG SCHOOLCHILDREN IN PORT-HARCOURT, NIGERIA.
Recently, monitoring blood pressure among paediatric population is being emphasized to allow for early detection and prevention of risk factors associated with hypertention. Few studies have highlighted the relationship...
A STUDY TO ASSESS THE RESILIENCE AMONG THE FAMILY MEMBERS OF PATIENT WITH ALCOHOL DEPENDENCE
• Handling a family member (men) with alcohol dependence is a challenging task for family members. Regular consumption of alcohol leads to domestic violence and other family problems. Alcohol Dependence is a group of phy...
A REVIEW ON ANTICANCER POTENTIAL OF THIAZOLE-HETEROCYCLIC HYBRID COMPOUNDS
In anticancer drugs, hybrid structure are of great therapeutic interest due they can potentially overcome most of the pharmacokinetic drawbacks. Thiazole-heterocyclic hybrid derivatives are another class of heterocyclic...
STUDY OF DYSPEPSIA WITH SPECIAL REFERENCE TO HELICOBACTER PYLORI
Background: Dyspepsia is a common condition that affects more than half of the population at some point during their lifetime. Oesophagogastroduodenoscopy (OGD) is recommended as the first investigation in the workup of...
DETOXIFICATION OF PATULIN MYCOTOXIN USING BY SEAWEED EXTRACT OF BROWN ALGAE ASCOPHYLLUM NODOSUM
The current study was focused on the ability of the foreign product seaweed extract of brown algae Ascophyllum nodosum to detoxifying of Patulin mycotoxin producing from Penicillium expansum. The results showed that seaw...