EVALUATION OF THE PROPHYLACTIC ROLE OF INDIAN SHRIMP IN ALUMINUM CHLORIDE-INDUCED ALZHEIMER’S DISEASE ON EXPERIMENTAL RATS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 3
Abstract
Objective: This work was aimed to investigate the prophylactic and therapeutic role of Indian shrimp in aluminum chloride-induced Alzheimer’s disease (AD) in rats. Methods: The male Wistar rats were selected and divided into six groups. Group I received distilled water, Group II received AlCl3 ( 100 mg/kg, p.o.), Group III received rivastigmine (1 mg/kg, p.o.), Group IV received AlCl3 + shrimp powder (200 mg/kg, p.o), and Group V received AlCl3 + shrimp powder (400 mg/kg, p.o) for 60 days. At the end of the study, various parameters such as behavioral and biochemical investigations were assessed. Results: The result of the study shows that the shrimp (400 mg/kg) has better effect on the treatment of aluminum chloride-induced AD in rats. It showed a remarkable improvement in the behavioral and biochemical parameters, and the result of histopathology study shows that the hippocampus region of brain tissue recovered as compared with control. Conclusion: From this study, it is evident that dietary intake of shrimp can help to inhibit oxidative stress produced due to the accumulation of AlCl3 in the brain and used as a prophylactic for AD.
Authors and Affiliations
RAMACHANDRAN S, SRI RAMYA M, LIZA U, LAKSHMI PRASANNA PS, SARISHMA K
Keywords
Related Articles
- EP ID EP603891
- DOI -
- Views 104
- Downloads 0
THE PHYSIOCHEMICAL AND ANTIBACTERIAL PROPERTIES OF GALACTOMANNAN EDIBLE FILM OF ARENGA PINNATA INCORPORATED WITH ZINGIBER OFFICINALE ESSENTIAL OIL
Objective: This study aimed to demonstrate the incorporation of Zingiber officinale essential (ZOE) oil onto galactomannan from Arenga pinnata (GAP) matrix and determined the antibacterial activity of the edible films (E...
CLEANING VALIDATION OF A SIMPLE AND RAPID REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR THE SIMULTANEOUS ESTIMATION OF ASPIRIN AND ROSUVASTATIN
Objective: This study describes a new, simple, precise, accurate, and reproducible reversed-phase high-performance liquid chromatography (RP-HPLC) cleaning validation method for simultaneous estimation of rosuvastatin an...
OPTIMIZATION, ISOLATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM STREPTOMYCES LAVENDULOCOLOR VHB-9
Objectives: Optimization, isolation, and characterization of bioactive compounds from Streptomyces lavendulocolor VHB-9 isolated from granite mines of Mudigonda village of Khammam district of Telangana state.Methods: The...
COMPARISON OF CARTILAGE TYPE IIIA AND IIIB TYMPANOPLASTY IN INDIAN PATIENTS WITH CHRONIC SUPPURATIVE OTITIS MEDIA
Objective: This prospective comparative study determined the efficacy of type III tympanoplasty using homologous septal spur cartilage in patients with chronic otitis medis (COM).Methods: We selected patients by random s...
DESIGN AND SYNTHESIS OF NOVEL IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND THEIR ANTI-BACTERIAL ACTIVITY
Objective: The present study aims to synthesize a novel derivatives of Imidazo[1,2-a]pyridines and the compounds were evaluated for their antibacterial activity.Methods: A series of newly synthesized compounds were chara...