Evaluation of thyroid profile in patients with endometrial cancer.
Journal Title: Journal of Indira Gandhi Institute of Medical Sciences - Year 2018, Vol 4, Issue 1
Abstract
BACKGROUND - Thyroid function has been suggested to interfere with tumour biology and affect the prognosis of various cancers. The present study was performed to evaluate pre-therapeutic serum thyroid-stimulating hormone (TSH) levels in all endometrial cancer (EC) and to study the relation between thyroid hormone and endometrial cancer. MATERIAL AND METHODS - This retrospective study was done in 46 diagnosed patients of endometrial cancer and a control group of 50 patients with no cancer. The pretheraputic levels of thyroid stimulating hormones were recorded and analysed. RESULTS - In our study we found significant number of endometrial cancer patient had deranged thyroid profile as compare to control group with p value 0.0057. Most of endometrial cancer patients were menopausal (86.96%) and mean BMI was 28.78 (in control BMI was 21.01). CONCLUSION - The results showed that TSH may increase the incidence of uterine cancer especially after menopause as it increases the BMI and estrogen and decreases adiponectin leading to hormonal imbalance. Hence TSH is a possible risk factor for uterine cancer especially after menopause. Thus women should pay attention to their thyroid function during menopausal age to reduce the risk of uterine cancer.
Authors and Affiliations
Jaya Kumar, Sangeeta Pankaj, Anita Kumari, Anjili Kumari, Syed Nazaneen, Setu Sinha, Vijayanand Choudhary, Rekha Kumari
Keywords
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