Evaluation of Total Antioxidant Activity and Its Relation with Serum Uric Acid in North Indian Elderly
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 7
Abstract
Aging process has been found to be associated with biomolecular destruction which in turn responsible for progression of age related complications. It is conceivable that alteration in plasma antioxidant reserve along with serum acid levels may have a crucial role in aging process. Aim: The objectives of present study were to ascertain the plasma levels of Total antioxidant activity (TAA) and serum uric acid (UA) in the subjects of different age groups and to determine their cumulative effect on lipid peroxidation with senescence. Methods: In the present study, 90 healthy subjects were selected and plasma TAA, serum UA and erythrocyte malondialdehyde (MDA) were measured using standard methods. Out of 90 subjects, 60 healthy individuals were categorized into two groups: Group I (40-55 years) and Group II (≥ 56 years) and statistically compared it with that of 30 younger controls (20-30 years) by using student’s t-test. Result: Plasma TAA levels were significantly low (p<0.05, p<0.001) in group I and II as compared to healthy controls. Similarly, erythrocyte MDA levels were significantly high (p<0.05, p<0.001) in group I and II as compared to healthy controls whereas serum uric acid levels were increased significantly (p<0.05) only in group II subjects. However, serum uric acid levels were altered insignificantly (p<0.1) in group I subjects as compared to younger controls. Conclusion: Our findings indicate that senescence is closely associated with altered plasma TAA and serum uric acid levels due to augmented oxidative stress and thereby making the elderly more susceptible to develop pathological consequences. Thus, consumption of antioxidant rich diet along with normal uric acid status could be an effective strategy to reduce the culprit effect of aging process. Keywords: Total antioxidant activity, free radical, inflammation, lipid per oxidation
Authors and Affiliations
Dr. Jusmita Dutta, Dr. Rahul Saxena, Dr. Dilutpal Sharma
Keywords
Related Articles
- EP ID EP373298
- DOI -
- Views 66
- Downloads 0
A Comparative Study of Activities of Daily Living (ADL) among Elderly Population Residing in Community Dwellings and Old Age Homes
Abstract: The population prevalence of older people has been growing worldwide. Quality of life among older people is a significant public health concern which primarily dependent on the activities of daily living. To co...
Streptococcus Mutans Adhesion of Different Bulk-Fill Resin-Based Composites
This study was conducted to evaluate Streptococcus Mutans Adhesion of Different Bulk-Fill Resin-Based Composites. Two bulk-fill resin based composites were used and one nano-hybrid resin based composite as a control. For...
Assistant Professor, Department of Ophthalmology, KIMS and PBMH, Bhubaneswar, Orissa
Abstract:Uveitis is a leading cause of ocular morbidity, most cases being idiopathic. The advent of steroid therapy has brought about drastic reduction in the incidence of ocular complications of uveitis....
Relation of senescence with systemic inflammation and serum paraoxanase activity: A clinical approach
It has been documented that the incidence of inflammation along with oxidative stress in biological system leads to the development of age related complications. However, the mechanism exploring the conundrum of senescen...
Serum Anti-Mullerian Hormone as a New Marker of Polycystic Ovary Syndrome
Abstract: Polycystic ovary syndrome is the most common endocrine disorder among women of reproductive age group. It is associated with number of health risks. Despite its frequency, the polycystic ovary syndrome (PCOS) i...