Evaluation of Total Antioxidant Activity and Its Relation with Serum Uric Acid in North Indian Elderly
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 7
Abstract
Aging process has been found to be associated with biomolecular destruction which in turn responsible for progression of age related complications. It is conceivable that alteration in plasma antioxidant reserve along with serum acid levels may have a crucial role in aging process. Aim: The objectives of present study were to ascertain the plasma levels of Total antioxidant activity (TAA) and serum uric acid (UA) in the subjects of different age groups and to determine their cumulative effect on lipid peroxidation with senescence. Methods: In the present study, 90 healthy subjects were selected and plasma TAA, serum UA and erythrocyte malondialdehyde (MDA) were measured using standard methods. Out of 90 subjects, 60 healthy individuals were categorized into two groups: Group I (40-55 years) and Group II (≥ 56 years) and statistically compared it with that of 30 younger controls (20-30 years) by using student’s t-test. Result: Plasma TAA levels were significantly low (p<0.05, p<0.001) in group I and II as compared to healthy controls. Similarly, erythrocyte MDA levels were significantly high (p<0.05, p<0.001) in group I and II as compared to healthy controls whereas serum uric acid levels were increased significantly (p<0.05) only in group II subjects. However, serum uric acid levels were altered insignificantly (p<0.1) in group I subjects as compared to younger controls. Conclusion: Our findings indicate that senescence is closely associated with altered plasma TAA and serum uric acid levels due to augmented oxidative stress and thereby making the elderly more susceptible to develop pathological consequences. Thus, consumption of antioxidant rich diet along with normal uric acid status could be an effective strategy to reduce the culprit effect of aging process. Keywords: Total antioxidant activity, free radical, inflammation, lipid per oxidation
Authors and Affiliations
Dr. Jusmita Dutta, Dr. Rahul Saxena, Dr. Dilutpal Sharma
Keywords
Related Articles
- EP ID EP373298
- DOI -
- Views 49
- Downloads 0
Vaginal candidiasis among pregnant women: A prevalence study
Abstract: Pregnant women frequently develop greater than before vaginal discharge which can lead to pregnancy difficulties like abortions, premature birth, low birth weight and other morbidities. The present study was ai...
Gastroesophageal Reflux Disease in Asthma
Asthma is one of the commonest chronic respiratory system diseases that affect a huge number world wild and it's incidence is increasing day by day, and it can affect the daily activity of the patient and cause disabilit...
Pattern of Antibiotics Used in the Pediatrics Indoor Department at Silchar Medical College and Hospital, Assam, India.
Abstract: Rational antibiotic prescription is very important to prevent antimicrobial resistance. This study was done to identify the commonly used antibiotics in the indoor pediatrics department at Silchar Medical Colle...
An Evaluation of Knowledge, Attitude and Practice of Breast Feeding Among Prescribers at Various Hospitals and Clinics in Pondicherry
The present study was undertaken to evaluate the knowledge, attitude and practices (KAP) regarding breast feeding among prescribers at various hospitals and clinics in Pondicherry and to get an insight into the reas...
Knowledge and awareness of the radiation safety among the medical students and resident doctors
Abstract: In day to day medical investigations radiations now become a must for the diagnosis. The radiations having most of the health risk for the doctors in constant contact with such procedures. During the learning p...