Serum Anti-Mullerian Hormone as a New Marker of Polycystic Ovary Syndrome

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Serum Anti-Mullerian Hormone as a New Marker of Polycystic Ovary Syndrome

Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 11

Abstract

Abstract: Polycystic ovary syndrome is the most common endocrine disorder among women of reproductive age group. It is associated with number of health risks. Despite its frequency, the polycystic ovary syndrome (PCOS) is still a difficult diagnosis in Endocrinology, Gynaecology, and Reproductive medicine. Many women with PCOS have high anti-mullerian hormone concentrations; thus, this may be a useful addition to the diagnostic criteria. The aim of this study was to estimate serum Anti-Mullerian hormone in diagnosed cases of PCOS and its role in diagnosis of PCOS. This is a hospital based prospective study. Here PCOS was diagnosed according to the Rotterdam criteria. 100 women diagnosed with PCOS (according to Rotterdam criteria) were recruited into the study. Most of the patients in the current study were in the age group of 26-30 years. The optimal serum AMH cut off value for PCOS diagnosis identified in this study was 5.7 ng/ml (from meta-analysis of various studies). 100 PCOS patients have been categorised into two groups as - group a (25) = AMH level< 5.7 ng/ml and group b (75) = AMH level>5.7 ng/ml. Mean AMH level in group a was 4.56 ng/ml and in group b was 12.28 ng/ml .It was found that the difference is highly significant at 0.01 level as p< 0.01. There were no correlation between BMI and AMH levels in all study groups (r= - 0.049 ; p = 0.628 ). A significant positive correlation was seen between serum testosterone, LH and AMH levels (r = 0.858, p<0.0001 and r= 0.245, p = 0.0138 respectively ). Therefore from this study, we can propose the potential application of AMH as a diagnostic marker for PCOS. Keywords: Polycystic ovary syndrome, antimullerian hormone, Rotterdam criteria, testosterone, follicle stimulating hormone.

Authors and Affiliations

R. K. Talukdar, Bivarani Goswami, Lungan Rongmei

Keywords

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