Evaluation of Vitamin D Level in Thyroid Disorder and its Correlation with Autoimmuity
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 6
Abstract
Vitamin D deficiency has become a global health problem. But it is most under-diagnosed and under-treated nutritional deficiency in the world [1–3]. Vitamin D was earlier known as a regulator of calcium homeostasis, and bone formation. Now many studies has indicated non skeletal functions of vitamin D also. Deficiency of vitamin D was also found to correlate with an increased incidence of autoimmune diseases, including type I diabetes mellitus (T1DM), [4] rheumatoid arthritis[5] and systemic lupus erythematosus.[6-8] It was reported that patients with Hashimoto’s thyroiditis, an autoimmune thyroid disease had lower vitamin D levels. [9] One recent study showed that the prevalence of vitamin D deficiency is higher in patients with AITDs and that the presence of anti-thyroid antibodies is significantly more common in patients with vitamin D deficiency than in those with higher vitamin D levels.[10] In contrast, another study performed in India revealed a weak association between low vitamin D levels and AITDs. Small case-control studies have suggested lower serum vitamin D levels or a higher prevalence of vitamin D insufficiency in patients with AITD compared with healthy controls.[11–16] In more recent years, the actions of vitamin D have been shown to go beyond calcium metabolism to include cell growth, differentiation, maturation and apoptosis, anticarcinogenic effects, and autoimmune activities .[17-18]
Authors and Affiliations
Ved Prakash
Keywords
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