Evalution of Cardiovascular Risk in Psoriasis Patients
Journal Title: PARIPEX-Indian Journal of Research - Year 2016, Vol 5, Issue 6
Abstract
Background-Psoriasis is a dermatological condition but its association with cardiovascular comorbidities is generating an increasing awareness that early diagnosis of associated cardiovascular risk factor like dyslipidemia can reduce morbidity, mortality and economic burden associated with the disease. Aim- The purpose of this study was to determine the serum lipid disturbances in patients of psoriasis and to see whether this is related to the severity of the disease. Setting and design- This was a case control study done in the department of Biochemistry, IGIMS, Patna, Bihar, India. Material and methods-A total of 130 subjects were included in the study. Sixty five were newly diagnosed patients of psoriasis and sixty five were non psoriatic individuals of age group 15- 50years. Serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels were estimated in both the groups. Psoriatic patients were divided into three groups as mild, moderate and severe based on PASI score. There were 22 patients of mild variety, 31 of moderate type and 12 of severe form. Result- Serum total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) levels were significantly raised in psoriatic group as compared to control group(p=0.01,0.04and 0.01 respectively). High density lipoprotein cholesterol (HDL-C) was decreased in psoriatic patients as compared to control but the decrease was not significant (p=0.32). ANOVA was calculated among the three groups of psoriatic patients with regard to TC, LDL-C and TG level. All three parameters showed positive correlation with severity but the increase with severity was significant only for LDL-C (p=0.004). Conclusion –Serum Total cholesterol, LDL-C and TG were significantly raised in patients of psoriasis and also showed increasing pattern with severity. So patients of psoriasis must be screened for dyslipidemia to avoid cardiovascular complications.
Authors and Affiliations
Bandana kumari, Uday kumar, Anand Saran, Rekha kumari, J. R. keshari, Indu Prasad
Keywords
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