Evidence for oxidative stress in osteoarthritis
Journal Title: Indian Journal of Clinical Biochemistry - Year 2005, Vol 20, Issue 2
Abstract
Evidence of increased oxidative stress in patients of osteoarthritis in comparison with healthy control subjects was investigated by measuring the thiobarbituric acid reactive substances (TBARS), vitamin C, reduced glutathione (GSH) and the activities of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) in erythrocytes. It was observed that osteoarthritis patients were more susceptible to oxidative damage than controls as evident from increased TBARS and decreased ascorbic acid, GSH, catalase and GPx in erythrocytes. Significant increase in SOD activity found in patients might be an adaptive response. With the understanding of the role of antioxidants in arthritis, it is becoming increasingly clear that these agents seem to be beneficial in osteoarthritis.
Authors and Affiliations
M Maneesh, H Jayalekshmi, T Suma, S Chatterjee, A Chakrabarti
Keywords
Related Articles
- EP ID EP112831
- DOI -
- Views 79
- Downloads 0
COMPARATIVE STUDY ON LIPID PEROXIDATION AND ANTIOXIDANT VITAMINS E AND C IN FALCIPARUM AND VIVAX MALARIA
Reactive oxygen species are thought to be involved in the pathogenesis of Malaria. To assess the extent of oxidative stress, a study was conducted in patients with Plasmodium falciparum malaria and Plasmodium Vivax mal...
SIGNIFICANCE OF TUMOR MARKERS IN LUNG CANCER
The objective was to test the utility of the cytokeratins CYFRA 21-1, tissue polypeptide specific antigen (TPS), Neuron specific enolase (NSE) and Carcino Embryonic antigen (CEA) in patients with lung cancer and in the...
BIOLOGICAL VARIATION OF PLASMA FERRITIN IN HEALTHY ADULT MALES IN SOUTH INDIAN POPULATION - A SAMPLE STUDY
A sample study of biological variation of plasma ferritin in healthy adult males 19-25 years of age (n = 6) in the Indian population was determined. Venous blood was collected on 3 non-consecutive days during a 3 week...
ANTIDIABETIC EFFECT OF T. ARJUNA BARK EXTRACT IN ALLOXAN INDUCED DIABETIC RATS
The present study was carried out to evaluate the antidiabetic effect of T.arjuna stembark extract and to study the activities of hexokinase, aldolase and phosphoglucoisomerase, and gluconeogenic enzymes such as glucos...
Association of Plasma Level of Thiobarbituric Acid Reactive Substances with Extent of Hepatocellular Injury in Preterm Infants with Cholestatic Jaundice
The present study was designed to determine the association between extent of hepatocellular injury and plasma level of thiobarbituric acid reactive substances (TBARS) in pre term infants with cholestasis. Preterm infant...