Evolution Of The Results Of 1500 Liver Transplantations Performed In The Department Of General, Transplant And Liver Surgery Medical University Of Warsaw
Journal Title: Polish Journal of Surgery - Year 2015, Vol 87, Issue 5
Abstract
Liver transplantation is a well-established treatment of patients with end-stage liver disease and selected liver tumors. Remarkable progress has been made over the last years concerning nearly all of its aspects. The aim of this study was to evaluate the evolution of long-term outcomes after liver transplantations performed in the Department of General, Transplant and Liver Surgery (Medical University of Warsaw). Material and methods. Data of 1500 liver transplantations performed between 1989 and 2014 were retrospectively analyzed. Transplantations were divided into 3 groups: group 1 including first 500 operations, group 2 including subsequent 500, and group 3 comprising the most recent 500. Five year overall and graft survival were set as outcome measures. Results. Increased number of transplantations performed at the site was associated with increased age of the recipients (p<0.001) and donors (p<0.001), increased rate of male recipients (p<0.001), and increased rate of piggyback operations (p<0.001), and decreased MELD (p<0.001), as well as decreased blood (p=0.006) and plasma (p<0.001) transfusions. Overall survival was 71.6% at 5 years in group 1, 74.5% at 5 years in group 2, and 85% at 2.9 years in group 3 (p=0.008). Improvement of overall survival was particularly observed for primary transplantations (p=0.004). Increased graft survival rates did not reach the level of significance (p=0.136). Conclusions. Long-term outcomes after liver transplantations performed in the Department of General, Transplant and Liver Surgery are comparable to those achieved in the largest transplant centers worldwide and are continuously improving despite increasing recipient age and wider utilization of organs procured from older donors.
Authors and Affiliations
Marek Krawczyk, Michał Grąt, Karolina Grąt, Maciej Krasnodębski, Jan Stypułkowski, Łukasz Masior, Wacław Hołówko, Joanna Ligocka, Paweł Nyckowski, Tadeusz Wróblewski, Rafał Paluszkiewicz, Waldemar Patkowski, Krzysztof Zieniewicz, Leszek Pączek, Piotr Milkiewicz, Urszula Ołdakowska-Jedynak, Bogusław Najnigier, Ireneusz Grzelak, Oskar Kornasiewicz, Marcin Kotulski, Mariusz Grodzicki, Marta Przybysz, Bartosz Cieślak, Małgorzata Nowosad, Konrad Kobryń, Jolanta Piwowarska, Dorota Giercuszkiewicz, Sławomir Rejowski, Monika Szydłowska-Jakimiuk, Barbara Górnicka, Bogna Wróblewska-Ziarkiewicz, Grzegorz Niewiński, Jacek Pawlak, Ryszard Pacho
Keywords
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- EP ID EP74481
- DOI 10.1515/pjs-2015-0046
- Views 109
- Downloads 0
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