EXCIPIENTS COPROCESSING INFLUENCE ON THE INTERACTING VARIABLES THAT AFFECT THE DISINTEGRATION PROPERTIES OF A PARACETAMOL TABLET FORMULATION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 5
Abstract
Objective: Neem gum (NMG) was coprocessed with lactose (LTC) at different ratios to produce novel binders.Methods: The quantitative individual and interaction effects of formulation variables, nature of the coprocessed binders (N), concentration of coprocessed binders (C) and their tablet’s relative density (D) on two disintegration properties–disintegration time (DT) and crushing strength-friability/disintegration time (CSFR/DT) ratio–of a Paracetamol tablet formulation was studied using a 23 factorial experimental design.Results: The result showed that changing from neem gum to any of the coprocessed binders decreases the disintegration time of the Paracetamol tablet while an increase in C of the coprocessed binders led to an increase in the CSFR/DT ratio of the Paracetamol tablets. The extent of this decrease in disintegration time or increase in CSFR/DT depends on the proportion of NMG or LTC in the coprocessed binders.Conclusion: The study concluded that the nature and proportions of individual materials coprocessed together would alter the influence C or D would have on disintegration time and CSFR/DT ratio. It further concludes that a 23 factorial analysis could be helpful to formulators in creating a design space for choosing optimal formulation and process variables that would produce desired product qualities.Keywords: Coprocessing, binder, Neem gum, Disintegration time, Crushing-strength-friability/disintegration-time ratio
Authors and Affiliations
Abayomi Tolulope Ogunjimi, Gbenga Alebiowu
Keywords
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