Excitatory amino acids and rheumatoid diseases
Journal Title: Reumatologia - Year 2005, Vol 43, Issue 6
Abstract
Excitatory amino acid (EAA), glutamate is a major neurotransmitter in the central nervous system. Its role in the periphery remains mostly unknown. Recently, EAA receptors there found on peripheral sensory terminals and dorsal root ganglion cells implicating their involvement in sensory and nociceptive transduction. The involvement of EAA mechanisms in inflammation was also suggested. It can be speculated that the use of EAA antagonists may provide a novel alternative for pharmacological intervention in joint inflammation and pain.
Authors and Affiliations
Jolanta Parada-Turska
Keywords
Related Articles
- EP ID EP82319
- DOI -
- Views 102
- Downloads 0
Zastosowanie przeciwciał monoklonalnych przeciw limfocytom B w terapii reumatoidalnego zapalenia stawów
W ostatnich latach nasza wiedza o udziale limfocytów B w patogenezie reumatoidalnego zapalenia stawów uległa znacznemu poszerzeniu. Obecnie uważa się, że limfocyty B odgrywają zasadniczą rolę w rozwoju reumatoidalnego...
Pathology of the cervical spine in rheumatoid arthritis
Infammatory changes of the cervical spine are reported in 25-80% of patients with rheumatoid arthritis. Atlanto-axial instability is the most common form of cervical involvement. The risk factors are: high disease activi...
New rheumatoid arthritis classification criteria
For the first time new classification criteria for rheumatoid arthritis have been presented by the joint working group of American rheumatologists from the American College of Rheumatology and European experts from th...
Patologia kręgosłupa szyjnego w reumatoidalnym zapaleniu stawów
U chorych na reumatoidalne zapalenie stawów zmiany zapalne w obrębie kręgosłupa szyjnego stwierdzane są w 25–80% przypadków. Najczęściej obserwuje się niestabilność w stawie szczytowo-obrotowym. Do czynników ryzyka należ...
Diagnostic of neuropsychiatric complications in vascular diseases in the course of systemic connective tissue diseases
Neuropsychiatric complications of systemic connective tissue diseases are currently the subject of interest of neurologists and rheumatolgists. Since the time that the new neuroimaging technics and serological and cerebr...