Exercise-induced time-dependent changes in plasma BDNF levels in people with schizophrenia
Journal Title: Journal of Novel Physiotherapy and Physical Rehabilitation - Year 2018, Vol 5, Issue 1
Abstract
Objective: To investigate the short and long-term outcomes of a concurrent exercise protocol (CEP) on plasma Brain-derived neurotrophic factor (BDNF) levels and the effect of this intervention in the self-esteem and mental health in people with schizophrenia (SZ). Methods: In this quasi-experimental study, 15 participants underwent a structured, supervised and group based CEP for 12 weeks (the sessions were performed 3 times a week for 60 minutes). In order to verify the short- and long-term effects of exercise on BDNF levels, blood samples of 15 ml were collected pre-intervention and on the 4th, 8th and 12th week(s) after intervention started. To evaluate self-esteem, the Rosemberg Self-esteem Scale was used, and the general mental health status was measured through the General Health Questionnaire-12 (GHQ-12). Both questionnaires were applied before and after intervention. Results: BDNF plasma levels increased significantly at the 12 th week(s) when compared to baseline and in 4 weeks periods. There were no observed changes on self-esteem neither a trend of improvement in the GHQ at the post-intervention phase when compared to the baseline. Finally, the CEP reduced significantly anthropometric variables. Conclusion: The CEP induced time-dependent modulation on BDNF levels in individuals with SZ, increasing its levels only in a long-term period.
Authors and Affiliations
Fuhr Laira, Lavratti Caroline, da Silva Ivy Reichert Vital, Reinaldo Gustavo Pereira, de Carvalho Nathan Ono, de Oliveira Jordana Lectzow, Wagner Luciane Carniel, Ribeiro Jerri, Elsner Viviane Rostirola
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- EP ID EP301035
- DOI 10.17352/2455-5487.000056
- Views 73
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