Experimental evaluation of anti convulsant and analgesic activity of a pyrimidine derivative 4CPTP
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 10
Abstract
Aim: To study the anti convulsant and analgesic activity of pyrimidine derivative 4CPTP. Material and methods: The anticonvulsant activity of 4CPTP (40, 60, 80 and 100 mg/kg) was assessed using maximum electroshock seizure (MES) test and metrazol test using albino mice. The tail flick test was used to assess the analgesic activity in rats. Results: 4CPTP produced dose dependent increase in the mean percentage of mice protected from electroshock and metrazol induced convulsions. The significant analgesic action of the drug was seen only at 100 mg/kg dose. Conclusions: 4 CPTP possesses anti convulsant and analgesic action in experimental animals.
Authors and Affiliations
Prem Kumar Verma, Garima Bhutani, Rahul Saini, Seema Rani
Keywords
Related Articles
- EP ID EP193750
- DOI -
- Views 66
- Downloads 0
Status of the Uncinate process in patients with sinusitis in a south Indian population- CT scan assisted anatomical and clinical study
Introduction: The Anatomical variations in the Uncinate process may alter the sinus outflow tract causing sinusitis. Aim: To find out the status of superior attachment of uncinate process and it variations with age and g...
A study of the cases of fatal burn injuries in tertiary care hospital, Assam – autopsy based study
Death due to burn injury constitutes a major portion of the cases brought for autopsy to the Department of Forensic Medicine, Silchar Medical College, Silchar, Assam. A proper study of these cases is the need of the hour...
Clinical profile and management of inguinoscrotal swelling in pediatric age group
Present study was undertaken in the department of Surgery from October 2013 to September 2015. 50 Children below 12 years age were selected for study who were present with inguinoscrotal swelling. Acute cases were exclud...
Immunohistochemical study of Her2/neu marker status in urothelial tumors of bladder
Background: Her2/neu is a marker of established clinical significance in the context of Her2/neu targeted therapy for breast carcinomas and gastric carcinomas. The present study was done to analyze the expression of Her2...
Study of serum Cystatin C, beta-2 microglobulin and protein carbonyl in diabetic nephropathy
Aim: Diabetic nephropathy is the leading cause of mortality due to long term uncontrolled hyperglycaemia related complications.The aim of present study was to evaluate clinical values of serum Cys-C and 2 microglobulin...