Experimental evaluation of anti convulsant and analgesic activity of a pyrimidine derivative 4CPTP
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 10
Abstract
Aim: To study the anti convulsant and analgesic activity of pyrimidine derivative 4CPTP. Material and methods: The anticonvulsant activity of 4CPTP (40, 60, 80 and 100 mg/kg) was assessed using maximum electroshock seizure (MES) test and metrazol test using albino mice. The tail flick test was used to assess the analgesic activity in rats. Results: 4CPTP produced dose dependent increase in the mean percentage of mice protected from electroshock and metrazol induced convulsions. The significant analgesic action of the drug was seen only at 100 mg/kg dose. Conclusions: 4 CPTP possesses anti convulsant and analgesic action in experimental animals.
Authors and Affiliations
Prem Kumar Verma, Garima Bhutani, Rahul Saini, Seema Rani
Keywords
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