Experimental evaluation of antidiabetic activity of syzygium aromaticum extract in streptozotocin induced diabetic rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2019, Vol 8, Issue 1
Abstract
Diabetes mellitus is a globally prevalent chronic debilitating illness. The goals in management of diabetes are to alleviate symptoms and signs of hyperglycaemia, and to prevent or reduce the acute and chronic complications of diabetes. There are a range of oral hypoglycaemic agents available for the treatment of diabetes but they are costly and have many adverse effects which warrant the continued research for newer drugs. In the present study, the flower buds of Syzygium aromaticum was studied for its antidiabetic activity against Streptozotocin (55mg/kg, i.p) induced diabetes in rats. 50% of ethanol was used as solvent to extract the constituents of Syzygium aromaticum buds. Three dose levels of Syzygium aromaticum (100, 300 and 500mg/kg) were used in the study. The test drugs were administered once daily for 15 days and the mean body weight, blood sugar were measured on 0, 5, 10 and 15th day using Glucometer and percentage reduction in blood sugar levels were also determined. All the doses of ethanolic bud extract of Syzygium aromaticum exhibited antidiabetic effect, but 500mg/kg showed significant antidiabetic effect as compared to other doses. From the result it was concluded that, Syzygium aromaticum exhibited antidiabetic effect against Streptozotocin induced diabetes in rats. Further studies are required to establish its anti-diabetic activity and to find out the exact mechanism for its anti-diabetic effect.
Authors and Affiliations
Ganesh Balram Saiprasanna
Keywords
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