Hypoglycemic effect of ethanolic extract of Hedychium coronarium linn., rhizome in alloxan induced diabetes in rat model
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2014, Vol 3, Issue 3
Abstract
Purpose To study the Hypoglycemic effect of ethanolic extract of Hedychium coronarium linn., rhizome in Alloxan induced diabetes in rat model. Methods The preliminary photochemical studies were carried out on the crude extract which was prepared and the various chemical constituents present in the crude extract were evaluated. Acute Toxicity studies as per OECD-23 guidelines to determine the safety doses of the root extract was carried out on mail wistar strain of Albino rats. The various factors such as body weight, feed intake, blood glucose, serum insulin etc were regularly studied and evaluated. Results The hypoglycemic effect of the ethanolic extract of Hedychium coronarium linn. Rhizome was studied on the various factors such as body weight, blood glucose levels etc of the alloxan induced diabetic rat model. Conclusion In present study administration of Hedychium coronarium rhizome extract produced a significant reduction in blood glucose, serum insulin, serum catalase and haemoglobin in alloxan induced rats. However, it seems promising that if these data will be validated in the future clinical trials, Hedychium coronarium rhizome extract may offer an alternative treatment for diabetes.
Authors and Affiliations
Pranitha. K
Keywords
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