Experimental Studies on the Effects of the Drug Septolete on Oral Cavity Immunity Factors
Journal Title: Здоров`я дитини - Year 2016, Vol 2, Issue 70
Abstract
Experimental studies in vitro were carried out in 120 samples under the conditions of Septolete (with various flavors, including Septolete plus as a spray and lozenges) contact with unstimulated oropharyngeal secretions and the blood serum of healthy donors. In vivo studies were conducted in five healthy donors to determine humoral factors to protect the oropharyngeal secretions before and one and two hours after Septolete plus lozenge dissolve in the oral cavity. Research results lead to the conclusion that Septolete plus manufactured by KRKA d.d., Slovenia, has no effect in in vitro contact conditions on the content of secretory IgA, other classes of serum immunoglobulins and does not alter the concentration of interferons α and γ. During in vivo study it was found that one hour after Septolete plus lozenge dissolve, we observed increase in the content of the secretory form of IgA.
Authors and Affiliations
O. F. Melnikov, A. D. Prylutska, M. D. Tymchenko
Keywords
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