Exploring the Mechanism of "Radix Bupleuri-Paeoniae Radix Alba" in the Treatment of Post-Stroke Depression Based on Network Pharmacology and Molecular Docking
Journal Title: Journal of Experimental and Clinical Application of Chinese Medicine - Year 2024, Vol 5, Issue 4
Abstract
Purpose: To explore the mechanism of “Radix Bupleuri-Paeoniae Radix Alba” in the treatment of post-stroke depression through network pharmacology and molecular docking. Methods: The active ingredients and targets of “Radix Bupleuri-Paeoniae Radix Alba” were predicted by Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. The related targets of post-stroke depression were searched in GeneCards, NCBI and DisGeNET databases. Cystoscape software was used to construct the “Chinese Medicine-Active Ingredient-Disease-Intersection Target” network, followed by Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. The active ingredients corresponding to the core targets were verified by molecular docking techniques. Results: A total of 145 potential core targets of “Radix Bupleuri-Paeoniae Radix Alba” in the treatment of post-stroke depression were identified. The core ingredients such as quercetin, kaempferol and β -sitosterol, and the key protein targets such as RAC-alpha serine/threonine-protein kinase 1 (AKT1), Interleukin-6 (IL-6) and Interleukin-1β (IL-1β) were screened out. KEGG pathway enrichment analysis mainly involved “lipids and atherosclerosis”, “chemical carcinogenesis-receptor activation”, and “hepatitis B”. Molecular docking results showed that quercetin and kaempferol, the main active ingredients of “Radix Bupleuri-Paeoniae Radix Alba”, had good affinity with the key potential targets AKT1, IL -6 and IL-1β. Conclusion: The pair of “Radix Bupleuri-Paeoniae Radix Alba” may act on the core targets such as AKT1, IL-6 and IL-1 β through the main active ingredients including quercetin and kaempferol, and may effectively treat post-stroke depression by regulating multiple signaling pathways such as “lipids and atherosclerosis” and “hepatitis B”.
Authors and Affiliations
Xia Zhou , Zhidong Zeng , Yanli Fu, Lei Chen
Keywords
Related Articles
- EP ID EP754225
- DOI -
- Views 30
- Downloads 0
The Therapy Based on Traditional Chinese Medicine for Otolithiasis
Background: Otolithiasis (also named benign paroxysmal positional vertigo, BPPV) is one of the most common illness for hospital visits. Residual dizziness and recurrence after reduction are problems for the treating BPPV...
Pharmacological Effects of Polygonati Rhizoma on "Tonifying the Kidney" and Its Development Status in the Field of Health Care
Polygonati Rhizoma has traditional effects of tonifying the kidney, with a wide clinical application. The record of Polygonati Rhizoma can be traced back to Miscellaneous Records of Famous Physicians, where Polygonati Rh...
Advancing Cardiovascular Health: Unveiling the Role of Traditional and Natural Medicine
In the quest for optimizing cardiovascular health, contemporary research increasingly explores the potential benefits of traditional and natural medicinal modalities. This paper provides insights into the therapeutic ave...
Exploring the Mechanism of Astragalus membranaceus in the Treatment of Post-Infectious Irritable Bowel Syndrome Based on Random Walk with Restart Algorithm and Experimental Validation
Background: This study aims to screen target genes with high relevance by running the random walk with restart (RWR) algorithm on the target background network, and to explore the mechanism of Astragalus membranaceus (AM...
Dynamic Changes of Phytohormone Concentrations during Prunella vulgaris L. Development and Impact of Rosmarinic Acid Accumulation through Exogenous ABA Application
Background: Plant hormones not only participate in regulating the growth and development process of plants, but also play an important regulatory role in the synthesis of secondary metabolites. Prunella vulgaris L. (P. v...