Exprerimental Evaluation of a Dedicated Pinhole SPECT System for Small Animal Imaging and Scintimammography
Journal Title: Engineering, Technology & Applied Science Research - Year 2011, Vol 1, Issue 1
Abstract
Nuclear medicine (SPECT and PET) provides functional information, which is complementary to the structural. In cancer imaging radiopharmaceuticals allow visualization of cancer cells functionality, thus small cell population can be imaged. This allows early diagnosis, as well as fast assessment of response to therapy. Our system is a single head gamma camera based on an R3292 position sensitive photomultiplier tube (PSPMT), coupled to a 10cm in diameter CsI:Tl crystal. We have assessed two CsI:Tl crystals with pixel size of 2x2mm2 and 3x3mm2 respectively. Three collimators were tested: a) a hexagonal, 1.1mm in diameter, general purpose parallel hole collimator b) a 1mm pinhole and c) a 2mm pinhole. Systems were tested using capillary phantoms. All measurements were carried out in photon counting mode with gamma radiation produced by 99mTc. Using the 2x2mm2 crystal and the 1mm pinhole collimator - a resolution better than 1mm was achieved. This allows very detailed imaging of small animals. Using the 3x3mm2 and the 2mm pinhole collimator a resolution of 1.3mm was possible with suitable sensitivity for breast imaging. Those results indicate that this system is suitable for animal and breast studies. The next step will be clinical evaluation of the camera.
Authors and Affiliations
S. David, M. Georgiou, E. Fysikopoulos, G. Loudos
Keywords
Related Articles
- EP ID EP84377
- DOI -
- Views 350
- Downloads 0
Block Milne’s Implementation For Solving Fourth Order Ordinary Differential Equations
Block predictor-corrector method for solving non-stiff ordinary differential equations (ODEs) started with Milne’s device. Milne’s device is an extension of the block predictor-corrector method providing further benefits...
A Demand Estimation Algorithm for Inventory Management Systems Using Censored Data
During the selling time horizon of a product category, a number of products may become unavailable sooner than others and the customers may substitute their desired product with another or leave the system without purcha...
A Simple Electronic Circuit for an Automatic Train Safety Stop System
A particular safety system known as “dead man’s circuit” detects the presence of human command in the conduction of the trains operated by the Brazilian Company of Urban Trains (CBTU) in Recife, Brazil, thus consisting a...
Using Neural Networks to Predict the Hardness of Aluminum Alloys
Aluminum alloys have gained significant industrial importance being involved in many of the light and heavy industries and especially in aerospace engineering. The mechanical properties of aluminum alloys are defined by...
Microscopical Characterization of Cast Hypereutectic Al-Si Alloys Reinforced with Graphene Nanosheets
This paper illustrates the effects of stirring and graphene nanosheet (GNS) addition on the microstructure and mechanical behaviour of 393 hypereutectic Al-Si alloys used in the diesel engine pistons. Two processing rout...