Expression of CD79b, CD25 and CD100 molecules on B cells in chronic lymphocytic leukemia (B-CLL)
Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 7
Abstract
<b>Introduction.</b> The CD79b, a component of the BCR complex plays an important role in lymphocyte B maturation and in the course of B-CLL. The α chain IL-2 receptor (CD25) and semaphorin Sema4D (CD100) are involved in B-CLL cells – microenvironment connections.<br><b>Aim.</b> The aim of this study was to analyze the relationship between CD79b expression and adverse prognostic factors CD38, ZAP-70 as well as CD25 and CD100 molecules.<br><b>Material and methods. </b>We analyzed peripheral blood samples from 113 B-CLL patients using three color flow cytometry with monoclonal antibodies.<br><b>Results.</b> In the patients with CD79b expression on B-CLL cells the CD38, ZAP-70 expression and disease progression were more frequently observed, as compared to those without CD79b expression. We also observed in CD79b positive patients a significantly higher percentage of cells with CD25 expression than in patients from groupCD79b negative. In 40/50 analyzed patients with CD100 expression on B-CLL cells, a positive correlation between CD38 expression and CD100 expression was defined, as well as high expression of CD25.<br><b>Conclusions.</b> Our results indicate that in CD79b positive patients is observed an „accumulation” of negative prognostic factors as well as expression of molecules responsible for interactions between B-CLL cells and the B-CLL microenvironment.
Authors and Affiliations
Joanna Kopeć-Szlęzak, Urszula Podstawka, Agnieszka Gajewska, Anika Sikorska
Keywords
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