Expression of DNA methyltransferase 1 and histone deacetylase 1 proteins in intraductal papillary mucinous neoplasms
Journal Title: Di-er Junyi Daxue Xuebao - Year 2008, Vol 29, Issue 11
Abstract
Objective:To investigate the expression of DNA methylation transferase 1 (DNMT1) and histone deacetylase 1 (HDAC1) proteins in intraductal papillary mucinous neoplasms (IMPNs) and its possible clinical significance.Methods:The presence of DNMT1 and HDAC1 proteins in the 48 IPMNs and 54 pancreatic ductal adenocarcinomas (PDACs) were examined using SP immunohistochemical method and were statistically analyzed.Results:The expression levels of both DNMT1 and HDAC1 increased in a malignancy-dependent manner:normal pancreatic ductal →IPMA,IPMB → IPMC → PDAC.And both of them were positive in IPMNs of different subtypes.Conclusion:Higher expression of DNMT1 and HDAC1 is an early event of pancreatic malignancy.Expression of them can reflect the malignancy transformation of IPMNs,but can not be used for histological typing of IPMNs.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP84211
- DOI -
- Views 96
- Downloads 0
Change of immunological response and cell proliferation in breast augmented by polyacrylamide hydrogel injection
Objective：To study the change of immunological response and cell proliferation in breast tissues augmented by polyacrylamide hydrogel injection(PHI).Methods:The expression of CD68,CD25 and PCNA in 20 breast tissues with...
结缔组织生长因子反义寡核苷酸体外对人增生性瘢痕成纤维细胞凋亡的影响
目的:观察结缔组织生长因子(CTGF)反义寡核苷酸(ASODN)体外对人增生性瘢痕组织中成纤维细胞凋亡的影响并探讨其可能的作用机制。方法：体外培养的人增生性瘢痕组织中成纤维细胞, 分为CTGF-ASODN 脂质体治疗组(ASODN treatment, AT)、空白脂...
Immune tolerance of dendritic cells and its role in graft rejection
As an antigen-presenting cell, dendritic cells (DCs)have drawn great attention due to its powerful antigen-presenting ability and immunological regulation function. Recently, it is believed that DCs also participate in r...
透皮促渗剂对双乌跌打损伤药方中胡椒碱体外经皮渗透的影响
目的:研究不同透皮促渗剂对复方跌打损伤药方中主要成分胡椒碱体外经皮渗透的促进作用。方法:采用Franz扩散池,选择氮酮、丙二醇、N-甲基吡咯烷酮（NMP）、油酸、薄荷油及其组合作为透皮促渗剂,以预处理的离体小鼠皮肤作为渗透屏障,HPLC 法...
Application of 64-slice spiral coronary CT angiography in diagnosis of restenosis in patients with coronary heart disease after stenting
Objective:To evaluate the clinical value of 64-slice spiral coronary CT angiography (CTA) in diagnosis of in-stent restenosis （ISR）after percutaneous coronary intervention(PCI) in patients with coronary artery disease....