趋化因子MIP-3α及其受体CCR6在溃疡性结肠炎中的表达及其意义
Journal Title: Di-er Junyi Daxue Xuebao - Year 2008, Vol 29, Issue 10
Abstract
目的:研究趋化因子巨噬细胞炎症蛋白-3α(MIP-3α)及其受体CCR6在溃疡性结肠炎(UC)中的表达情况以及与UC病变程度和范围的关系,探讨其在UC发病机制中的作用。方法:用免疫组织化学法检测35例活动期UC及20例正常对照石蜡包埋组织中MIP-3α及CCR6的表达情况。结果:UC组MIP-3α及CCR6均为阳性表达，对照组为阴性或弱阳性表达。MIP-3α及CCR6在UC组的表达与对照组相比,差异有统计学意义(P＜0.01)。UC病变范围越广、程度越重,MIP-3α及CCR6表达阳性率越高；且MIP-3α和CCR6表达有明显相关性(r=0.765,P＜0.01)。 结论:MIP-3α与CCR6均参与了UC的发生和发展,两者的相互作用可能在UC局部结肠组织破坏和病理变化中起着重要作用。
Authors and Affiliations
Wan-e ZHONG
Keywords
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