趋化因子MIP-3α及其受体CCR6在溃疡性结肠炎中的表达及其意义

Journal Title: Di-er Junyi Daxue Xuebao - Year 2008, Vol 29, Issue 10

Abstract

目的:研究趋化因子巨噬细胞炎症蛋白-3α(MIP-3α)及其受体CCR6在溃疡性结肠炎(UC)中的表达情况以及与UC病变程度和范围的关系,探讨其在UC发病机制中的作用。方法:用免疫组织化学法检测35例活动期UC及20例正常对照石蜡包埋组织中MIP-3α及CCR6的表达情况。结果:UC组MIP-3α及CCR6均为阳性表达,对照组为阴性或弱阳性表达。MIP-3α及CCR6在UC组的表达与对照组相比,差异有统计学意义(P<0.01)。UC病变范围越广、程度越重,MIP-3α及CCR6表达阳性率越高;且MIP-3α和CCR6表达有明显相关性(r=0.765,P<0.01)。 结论:MIP-3α与CCR6均参与了UC的发生和发展,两者的相互作用可能在UC局部结肠组织破坏和病理变化中起着重要作用。

Authors and Affiliations

Wan-e ZHONG

Keywords

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  • EP ID EP84204
  • DOI -
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How To Cite

Wan-e ZHONG (2008). 趋化因子MIP-3α及其受体CCR6在溃疡性结肠炎中的表达及其意义. Di-er Junyi Daxue Xuebao, 29(10), 1180-1183. https://europub.co.uk/articles/-A-84204