Expression of p53 Protein by Immunohistochemistry in Urothelial Neoplasm: A Hospital-based Study from Eastern India
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 8
Abstract
Background: It is diffi cult to predict which urothelial neoplasm would subsequently recur or progress to muscle invasive tumors or produce metastasis. Objectives: The aim and objective of the study were to evaluate the scope of immunohistochemical grading of p53 inurothelial neoplasms with regard to grade and histopathological pattern. Materials and Methods: Forty-fi ve consecutive patients were taken, and samples were obtained from transurethral resection. Histopathological examinations were performed, and the grading was done according to the World Health Organization/ International Society of Urological Pathology consensus classifi cation of urothelial neoplasms. Immunohistochemical staining for p53 was performed on formalin-fi xed paraffi n-embedded tissue sections with appropriate positive and negative control. Results: We found 5 patients of papillary urothelial neoplasm of low malignant potential (PUNLMP), 12 cases of non-invasive low-grade papillaryurothelial carcinoma, and 18 patients with non-invasive high-grade papillaryurothelial carcinoma including 10 cases of invasive urothelial carcinoma. All 5 PUNLMP cases showed negative results. 3 of 12 low-grade papillary urothelial carcinoma had high nuclear p53 accumulation, while all of the 16 papillary high-grade carcinomas had high p53 index. All the invasive urothelial carcinomas were high p53 expressor. Conclusion: A trend of expression of p53 in urothelial neoplasm supports the notion that mutation of p53 gene might be unrelated to the development of urothelial neoplasms but defi nitely play a crucial role in progression of the malignancy.
Authors and Affiliations
Roy Chowdhury Anadi, Ranjan Kumar Dey
Keywords
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