Expression of p63 in Benign, In-Situ and Invasive Ductal Carcinoma of Breast
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 11
Abstract
Background: p63 is a member of p53 family of transcription factors which have important function in tumorogenesis and oncogenesis. It is involved in cellular differentiation and exposed in nuclei of myoepithelial cells of normal breast. Aim: To study immunoexpresion of p63 in the benign, insitu, and invasive ductal carcinoma of breast. Material and Methods: The present study was conducted on 110 cases of formalin fixed paraffin embedded histological sections of surgically resected breast tissue specimens suspected to have neoplastic lesions and mastectomy specimens already diagnosed as carcinoma on cytology for a period of one year. Result: p63 is strongly expressed in all benign breast lesion in form of continuous peripheral rim around ductal epithelial cells, except atypical ductal hyperplasia in which moderate expression of p63 was noted in form of scattered as less continuous rim of myoepithelial cells similarly moderate to weak expression with focal gaps was described in ductal carcinoma of in situ and no expression was noted in infiltrative ductal carcinoma. Conclusion: p63 is a hallmark of very poorly differential cells or cells component with higher histological grade in breast carcinoma. Hence p63 can be used as an indicator of aggressiveness of breast carcinoma as a marker of choice in differentiating benign and malignant breast lesions.
Authors and Affiliations
Rajesh Kumar Rai
Keywords
Related Articles
- EP ID EP530130
- DOI 10.21088/ijprp.2278.148X.71118.12
- Views 77
- Downloads 0
Morphological Spectrum of Endometrium in Dysfunctional Uterine Bleeding
Introduction: Dysfunctional uterine bleeding (DUB) is defined as increased abnormal endometrial bleeding unrelated to any anatomic lesions/ organic pathology of the genital tract [1]. It is a common problem in woman of r...
Noise Pollution
N\A
Immunohistochemical Expression of P53 and Ki-67 Antigen in Premalignant and Malignant Oral Lesions
Background: p53 protein is a product of TP53 tumor Suppressor gene. TP53 mutations leading to loss of function are the commonest type of genetic damage found in human cancers and oral squamous cell carcinomas, often prec...
Corneal Pyogenic Granuloma–A Case Report with Review of Literature
Background: Pyogenic granuloma is an excessive proliferation of granulation tissue that usually develops after minor trauma or surgery. Ocular involvement usually happens on the external surface and cornea is rarely invo...
Premalignant Lesions and Incidental Carcinoma in Clinically Diagnosed Benign Prostatic Hyperplasia (BPH)
Background: Histological examination of the prostate must also include the description of some important aspects which are present associated with Benign Prostatic Hyperplasia (BPH) and which may condition the progressio...