Expression of p63 in Benign, In-Situ and Invasive Ductal Carcinoma of Breast
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 11
Abstract
Background: p63 is a member of p53 family of transcription factors which have important function in tumorogenesis and oncogenesis. It is involved in cellular differentiation and exposed in nuclei of myoepithelial cells of normal breast. Aim: To study immunoexpresion of p63 in the benign, insitu, and invasive ductal carcinoma of breast. Material and Methods: The present study was conducted on 110 cases of formalin fixed paraffin embedded histological sections of surgically resected breast tissue specimens suspected to have neoplastic lesions and mastectomy specimens already diagnosed as carcinoma on cytology for a period of one year. Result: p63 is strongly expressed in all benign breast lesion in form of continuous peripheral rim around ductal epithelial cells, except atypical ductal hyperplasia in which moderate expression of p63 was noted in form of scattered as less continuous rim of myoepithelial cells similarly moderate to weak expression with focal gaps was described in ductal carcinoma of in situ and no expression was noted in infiltrative ductal carcinoma. Conclusion: p63 is a hallmark of very poorly differential cells or cells component with higher histological grade in breast carcinoma. Hence p63 can be used as an indicator of aggressiveness of breast carcinoma as a marker of choice in differentiating benign and malignant breast lesions.
Authors and Affiliations
Rajesh Kumar Rai
Keywords
Related Articles
- EP ID EP530130
- DOI 10.21088/ijprp.2278.148X.71118.12
- Views 75
- Downloads 0
Clinicopathological Correlation of Thyroid Cytology with Thyroid Function Tests: A Study of 100 Cases
Background: Thyroid Swellings are most common in routine clinical practice. Fine needle aspiration cytology (FNAC) gives quick results with good sensitivity and specificity. It minimize further investigations and surgeri...
Histopathological spectrum of adrenal gland lesions
Introduction: Suprarenal gland is a bipartite endocrine gland which is divided into adrenal cortex and adrenal medulla. Histopathological spectrum of adrenal lesions consist of adrenal cysts, adrenal myelolipoma, adrenal...
A Histopathologic Study of Papulosquamous Lesions of Skin
Papulosquamous group of skin lesions have certain common clinical presentations and lead to confusion in diagnosis. We undertook this study to analyze the histomorphological findings of various papulosquamous lesions of...
Increased Mast Cell Density in Axillary Lymph Nodes without Metastasis in Breast Carcinoma: A Possible Protective Role
Introduction: One of the most important prognostic factors in breast cancer is metastasis to regional lymph nodes resulting in a reduced overall survival rate. Mast cells in tissue release both pro-tumourigenic and anti...
Histomorphological Pattern of Testicular Lesions in Orchidectomy Specimens: A Retrospective Study
Background: Testis is affected by various non neoplastic and neoplastic lesions. Non neoplastic lesions include congenital anomalies, inflammatory, infective, vascular lesions, cysts, and atrophy. The incidence of testic...