Expression of p63 in Benign, In-Situ and Invasive Ductal Carcinoma of Breast
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 11
Abstract
Background: p63 is a member of p53 family of transcription factors which have important function in tumorogenesis and oncogenesis. It is involved in cellular differentiation and exposed in nuclei of myoepithelial cells of normal breast. Aim: To study immunoexpresion of p63 in the benign, insitu, and invasive ductal carcinoma of breast. Material and Methods: The present study was conducted on 110 cases of formalin fixed paraffin embedded histological sections of surgically resected breast tissue specimens suspected to have neoplastic lesions and mastectomy specimens already diagnosed as carcinoma on cytology for a period of one year. Result: p63 is strongly expressed in all benign breast lesion in form of continuous peripheral rim around ductal epithelial cells, except atypical ductal hyperplasia in which moderate expression of p63 was noted in form of scattered as less continuous rim of myoepithelial cells similarly moderate to weak expression with focal gaps was described in ductal carcinoma of in situ and no expression was noted in infiltrative ductal carcinoma. Conclusion: p63 is a hallmark of very poorly differential cells or cells component with higher histological grade in breast carcinoma. Hence p63 can be used as an indicator of aggressiveness of breast carcinoma as a marker of choice in differentiating benign and malignant breast lesions.
Authors and Affiliations
Rajesh Kumar Rai
Keywords
Related Articles
- EP ID EP530130
- DOI 10.21088/ijprp.2278.148X.71118.12
- Views 63
- Downloads 0
Cytomorphological Patterns of Tuberculous Lymphadenitis in Correlation with AFB Positivity
Objective: Despite progress in prophylaxis and treatment modalities, tuberculous (TB) lymphadenitis still remains a major health problem in developing countries. In India, extrapulmonary TB accounting 20% of all TB cases...
A Study on Histological Classification of Bone Lesions and Features of Malignant Lesions: Descriptive Study
Introduction: Osteosarcoma is by far the greatest histological imitator of bone tumours. Both radiologically and histologically, osteosarcoma mimics many other benign and malignant bone lesions.Accurate diagnosis of bone...
Utility of Mucin Histochemistry in Prostatic Neoplasms with Review of Historical Background
Introduction: The prostatic cancer is the second most common cause of cancer death in men. Aim: To elaborate the study of mucin histochemistry in prostatic lesions and establish theutility of Mucin Stains in distinguish...
Accuracy of Intraoperative Frozen Section inthe Diagnosis of Ovarian Neoplasms in a Tertiary Care Centre
Background: Frozen section is an important tool in the intraoperative diagnosis of ovarian tumours which guides the surgeon in tailoring the surgical therapy, especially in younger women. Aim: To determine the accuracy o...
A Study of Histopathological Analysis of Endometrium in Abnormal Uterine Bleeding in a Tertiary Care Centre
Context: Abnormal uterine bleeding (AUB) is an important clinical entity in females. Aims: The objective of the study was to study the histopathological (HPE) features of endometrium and to correlate its incidence with a...