Premalignant Lesions and Incidental Carcinoma in Clinically Diagnosed Benign Prostatic Hyperplasia (BPH)
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 4
Abstract
Background: Histological examination of the prostate must also include the description of some important aspects which are present associated with Benign Prostatic Hyperplasia (BPH) and which may condition the progression of the disease. Aim: To find out incidence of Prostatic Intraepithelial Lesions (PIN) and incidental carcinoma in clinically diagnosed BPH, and to correlate histological findings with patients age and pre-operative serum PSA (prostate specific antigen) level. Method and Material: 107 TURP (Trans Urethral Resection of Prostate) specimens were processed and studied. Histomorphological diagnosis is made. Correlation of final histological diagnosis with age and serum PSA level, applying one way ANOVA test, was determined. Results: Out of 107 cases, the incidence of Low Grade PIN was 2 (1.9%), High Grade PIN was 1 (0.9%) and overall PIN was 3 (2.8%). The incidence of T1a was 4 (3.7%), of T1b was 2 (1.9%) and overall prostatic carcinoma was 6 (5.6%). Of these, there were 2 (33.3%) patients in the Gleason Grade 1 and 4 (66.7%) in the Gleason Grade 2. Statistically significant correlation of these premalignant and malignant lesions is demonstrated in comparison to age, whereas serums PSA level do not show any significant correlation. Conclusion: Both, adenocarcinoma and PIN can be diagnosed on histopathological examination of TURP specimen. Probability of finding these premalignant lesions as well as incidental carcinoma in association with BPH increases with age.PSA levels are not significant indicator of presence of
Authors and Affiliations
Tignath Aditya
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- EP ID EP520747
- DOI 10.21088/ijprp.2278.148X.7418.7
- Views 57
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