Expression of Steroid Hormone Receptors of the Cervix in Cervical Intraepithelial Neoplasia Associated with Human Papillomavirus Infection in Infertile Women
Journal Title: Міжнародний ендокринологічний журнал - Year 2014, Vol 8, Issue 64
Abstract
The article presents the results of immunohistochemical study of estrogen and progesterone receptors of the cervix in cervical intraepithelial neoplasia (CIN) associated with human papillomavirus infection (HPI) in 157 women with impaired reproductive function. Depending on CIN severity all cases were divided into three groups: the first group — 62 patients with mild CIN (CIN-I); the second group — 53 women with moderate CIN (CIN-II); the third group — 42 patients with severe CIN (CIN-III). Monoclonal antibodies to estrogen (ER) (clone 6F11, Novocastra) and progesterone receptors (PgR) (clone 1A6, Novocastra) were used as primary ones. When studying receptor status of cervical tissue in CIN, there are significant changes in the intensity of ER and PgR receptors expression. Immunohistochemical reaction in terms of identification of estrogen receptors is positive in 29.9 % of cases, negative — in 70.1 %. Positive PgR expression is set in 31.2 % of women with CIN, negative expression — in 68.8 %. In CIN and HPI, the redistribution of steroid receptors expression is marked, since ER is characterized by decrease of epithelial and appearance of stromal positive reaction. PgR expression differs by positive epithelial extinction with expressed nonspecific reaction in stromal component of the cervix. Estimation of hormone-receptor system of the cervix showed a significant decrease (p < 0.05) in ER volume content (twice) in comparison with PgR (1.3 times). In CIN associated with HPI, a significant decrease in ER/PgR ratio is noted, with the lowest parameter in the group of patients with CIN-III (p < 0.05). Therefore, detection of the expression of steroid hormone receptors in cervical neoplasia associated with HPI in infertile women can be used as an additional criterion for determining the degree of dysplastic process in cervical epithelium.
Authors and Affiliations
E. O. Kindrativ
Keywords
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