Extended-spectrum β-lactamases (ESBL) -producing Escherichia coli strains in blood culture
Journal Title: Human & Veterinary Medicine - International Journal of the Bioflux Society - Year 2011, Vol 3, Issue 2
Abstract
Introduction: Extended-spectrum beta-lactamase (ESBL)–producing Escherichia coli (E.coli), are major pathogens responsible for bacteraemia. The CTX-M types of ESBL are becoming dominant worldwide, particularly CTX-M-15. Bacteraemia caused by these strains is difficult to treat because the organisms are frequently resistant to the antimicrobials recommended for treatment of patients. Methods: We included in our study all consecutive episodes of bloodstream infection due to ESBL-producing E. coli during the period January 2007 - December 2010. Strains were isolated, and tested for antimicrobial resistance using Vitek2 system and API Biomerieux. ESBLs were characterized using polymerase chain reaction (PCR). Results: 127 episodes of E. coli bacteraemia, 30 ESBL-producing E. coli (24%) were included; 90% (19 strains) of the molecular characterizated isolates produced a CTX-M type of ESBL. The most frequent origins of infection were urinary tract (24%) and intraabdominal infections (11%). Coresistance to other antimicrobials was important between ESBLproducing strains. The majority of isolates were resistant to ciprofloxacin 22 strains (73%) andgentamicin 21 strains (70%). Conclusions: ESBL-producing E. coli is a significant cause of bloodstream infection in the context of the emergence of CTX-M enzymes. Empirical treatment of sepsis potentially caused by E. coli may need special attention in areas where such ESBL-producing isolates are present.
Authors and Affiliations
Mirela Flonta, Cornelia Craciunaş, Mihaela Lupşe, Ariana Almaş, Dumitru Cârstina
Keywords
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