The consequences of aluminium sulphate intake on exposure and integrity biomarkers in female rats at sexual maturity (two generation study).
Journal Title: Human & Veterinary Medicine - International Journal of the Bioflux Society - Year 2010, Vol 2, Issue 1
Abstract
The aim of the study was the assesment of alumnium toxic impact on female reproductive system integrity and performances biomarkers. The objectives were: the evaluation of aluminium levels in ovary, Fallopian tubes and uterus (exposure biomarker) and the structural changes in ovary, Fallopian tubes and uterus (integrity biomarker) at sexual maturity consecutive exposure to aluminium sulphate (200, 400, 1000 ppb Al) in drinking water along two generations (F0, F1). The study pointed out significant increase of aluminium level in ovaries, Fallopian tubes and uterus comparative to the control group and direct corelation, with different degrees of significance, with the exposure level; severe congestive and degenerative changes in ovary and uterus. The studies regarding aluminium reproductive toxicity are few and sometimes controversially (Andrews 1993).
Authors and Affiliations
Alexandra Trif, Eugenia Dumitrescu, Diana Brezovan, Snejana Petrovici
Keywords
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