Extent of antimicrobial resistance in Acinetobacter species in a Tertiary Care Teaching Hospital
Journal Title: Indian Journal of Microbiology Research - Year 2018, Vol 5, Issue 2
Abstract
Acinetobacter, gram negative coccobacillus, has become a frequent pathogen in hospitals and other health care settings. Acinetobacter species cause a wide variety of illness in debilitated and hospitalized patients especially in intensive care units (ICU). Carbapenems constitute the backbone of treatment of complicated Acinetobacter infections. However, resistance to Carbapenem is established and observed globally, leading to limited therapeutic options. The study was designed to understand the extent of resistance in Acinetobacter species in our hospital which is located in an island separated from mainland India. Isolates showing resistance to either Imipenem (IMP) and/or Meropenem by disc diffusion method was considered as Carbapenamase producing and further subjected to identification by phenotypic methods. Of the 160 isolates, 111 were resistant to either Imipenem and/or Meropenem. The susceptibility patterns of antibiotics tested suggests high resistance to 3rd/4th generation Cephalosporins (CTR 93.7%, CAZ 88.29%, CPM 85.59%) and least resistance to Colistin and Polymyxin B. MHT alone was positive in 66.98% isolates suggesting production of OXA type class D ?-lactamase and DDST alone was positive in 7.55% isolates suggesting production of Metallo-?-lactamase /Group B ?-lactamase. The present study adds to the literature available in respect to increasing instances of Carbapenem resistance and their presumptively mechanism of resistance.
Authors and Affiliations
Sanjeev H, Abhay Kumar, K. Snehaa, Amit Banik, Amber Prasad
Keywords
Related Articles
- EP ID EP472830
- DOI 10.18231/2394-5478.2018.0038
- Views 71
- Downloads 0
Prevalence and antibiotic pattern of group B streptococcus among antenatal women attending a tertiary care centre in Puducherry
Introduction: Colonization with Streptococcus agalactiae or group B Streptococcus (GBS) among antenatal mothers has become an important element which can affect the prognosis of meningitis and sepsis in neonates. Pregnan...
Comparison of Phenotypic and molecular profile of Coagulase negative Staphylococci from clinical isolates and commensals along with Biofilm detection
Background: Coagulase-Negative Staphylococci (CoNS) are commensals of the human skin and mucosa. However, Staphylococcus epidermidis (S. epidermidis) and other CoNS have emerged as nosocomial pathogens. This study aims t...
Biosurfactant: Types, Detection Methods, Importance and Applications
There are many insoluble substrates that remain unavailable for macro and micro organisms. A microorganism synthesizes surface active agents to utilize these substrates that are collectively called as biosurfactants. Bio...
Mutagenesis and screening of Penicillium oxalicum (Dal 5) for enhancing cellulase production
In the modern era due to increasing fuel demand prices of crude oil is increasing day by days So the need for bioenergy sources is increasing in coming years Of all the biomass present in the world lignocelluloses as ind...
Aerobic Bacterial and fungal profile with antimicrobial susceptibility in patients of CSOM attending tertiary care hospital
Chronic Suppurative Otitis Media (CSOM) is a long standing infection of a part or whole of the middle ear cleft characterized by ear discharge & various complications if not treated especially in developing countries wit...