Extracellular vesicles in the blood components and their roles in transfusion-related immunomodulation
Journal Title: Chinese Journal of Blood Transfusion - Year 2022, Vol 35, Issue 8
Abstract
Extracellular vesicles (EVs) with a variety of bioactive molecules can be continuously secreted during the storage of blood components, which can promote cell-cell interaction and mediate cell-to-cell signal transmission. EVs are widely involved in inflammation, metabolism and immunization. In recent years, studies have reported that EVs in the blood components can not only cause transfusion-related lung injury through activating neutrophils, but also act on monocytes to stimulate inflammatory response. EVs can play different regulatory effects on the immune system of patients. In this review, the role and mechanism in transfusion-related immunomodulation (TRIM) of EVs in different blood components have been summarized.
Authors and Affiliations
Yujie KONG, Xue TIAN, Li TIAN, Zhong LIU
Keywords
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- EP ID EP738332
- DOI 10.13303/j.cjbt.issn.1004-549x.2022.08.025
- Views 88
- Downloads 0
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