Extracorporeal Irradiation in Management of Primary Bone Tumors- An Institutional Experience
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2017, Vol 19, Issue 1
Abstract
Primary bone tumor, which has made limb salvage possible. It consists of en-bloc removal of the tumor bearing bone segment, removal of the tumor from the bone, irradiation and reimplantation of the Extracorporeal Irradiation (ECI) is a relatively newer method of delivering radiation in patients of bone. We report our preliminary experience of using ECI for management of Primary bone tumors at our institute. From year 2014 to 2016, Six patients with primary bone tumor were enrolled. Four patients were of Ewings’sarcoma (ES) and two of Osteosarcoma (OS). The eligibility criteria included histopathological proof of malignancy, no evidence of distant metastases at the time of surgery, and suitability for limb preservation therapy. Surgery was performed about 4 weeks after completion of neoadjuvant chemotherapy. The affected bone segment was resected, irradiated extracorporeally with a dose of 50 Gray and re-implanted. Local control and complications was studied. Out of the six patients treated so far, none of them developed local recurrence at the median follow up of 11 months. One patient developed systemic metastasis and one developed chemotherapy related complications during adjuvant chemotherapy. Results of our study suggest that ECI is technically feasible in the management of Primary bone tumors and provides decent local control with no complications. A larger study with more number of patients and longer follow up is required to draw further conclusions.
Authors and Affiliations
Sonal Patel, U Suryanarayan, Jyoti Poddar, Jaymin Shah, Abhijeet Salunke, Satish Pelagade
Keywords
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