Successful Management of Vincristine Induced Unilateral Ptosis in an Adult
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2016, Vol 18, Issue 1
Abstract
Vincristine (VCR) is a vinca alkaloid widely used in the treatment of lymphoma, leukemia and solid tumours.VCR is neurotoxic and it usually causes peripheral neuropathy,but cranial and autonomic neuropathy are uncommon side effects. This case report describes the successful management of Vincristine induced unilateral ptosis in an adult patient of Burkitt lymphoma. Patient was given cytoreductive chemotherapy i.e. CVP (cyclophosphamide,vincristine and steroids).On post chemotherapy day-3,he developed acute onset of left eye ptosis. Patient’s neurological examination revealed only unilateral ptosis with normal pupillary and corneal reflex. Other cranial nerves, peripheral nerves and other neurological findings were normal. Magnetic resonance imaging of brain and cerebrospinal fluid examination was normal. Patient was started on pyridoxine and pyridostigmine. Ptosis markedly improved after 5 days of treatment. The case has been reported in view of rarity of this complication.
Authors and Affiliations
Gautam Makadia, Sonia Parikh, Harsha Panchal, Asha Anand, Apurva Patel, Sandip Shah, Pritam Kalaskar
Keywords
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