Retrospective Analysis of Hypofractionated Radiotherapy for Palliation of Locally Advanced Head and Neck Cancers
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2013, Vol 15, Issue 1
Abstract
A retrospective study of the fifty locally advanced head and neck cancers patients treated with palliative hypofractionated radiotherapy at Gujarat Cancer and Research Institute was carried out to find out efficacy and toxicity profile of the treatment schedule. Fifty patients without curative treatment options were treated with 45 Gy in 15 fractions, 3 Gy per fraction in 3 weeks. Endpoints of the study were response rates, toxicity, disease-free survival overall survival at one year. Ninety eight per cent of patients were male, more than 26% had oropharyngeal cancer and all were stage IV disease. Complete response and partial response rates were 22% and 46%, respectively. Overall response rate of 68% was achieved. Twenty four percent had stable disease, and 8% progressed during or directly after completion of treatment. Disease-free survival and overall survival were 32% and 54% at 1- year, respectively. Acute grade III skin and mucosal toxicities were observed in 4% and 10% of patients, respectively. In conclusions, our hypofractionated radiotherapy scheme is an effective, well-tolerated and safe palliative schedule in locally advanced head and neck cancers patients who are unsuitable for curative treatment options and it achieved excellent palliation with acceptable response rates, symptomatic improvement and acceptable toxicity profile.
Authors and Affiliations
Maulik Bhensdadia, Rakesh Vyas, Jayprakash Neema
Keywords
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- EP ID EP213136
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