Retrospective Analysis of Hypofractionated Radiotherapy for Palliation of Locally Advanced Head and Neck Cancers
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2013, Vol 15, Issue 1
Abstract
A retrospective study of the fifty locally advanced head and neck cancers patients treated with palliative hypofractionated radiotherapy at Gujarat Cancer and Research Institute was carried out to find out efficacy and toxicity profile of the treatment schedule. Fifty patients without curative treatment options were treated with 45 Gy in 15 fractions, 3 Gy per fraction in 3 weeks. Endpoints of the study were response rates, toxicity, disease-free survival overall survival at one year. Ninety eight per cent of patients were male, more than 26% had oropharyngeal cancer and all were stage IV disease. Complete response and partial response rates were 22% and 46%, respectively. Overall response rate of 68% was achieved. Twenty four percent had stable disease, and 8% progressed during or directly after completion of treatment. Disease-free survival and overall survival were 32% and 54% at 1- year, respectively. Acute grade III skin and mucosal toxicities were observed in 4% and 10% of patients, respectively. In conclusions, our hypofractionated radiotherapy scheme is an effective, well-tolerated and safe palliative schedule in locally advanced head and neck cancers patients who are unsuitable for curative treatment options and it achieved excellent palliation with acceptable response rates, symptomatic improvement and acceptable toxicity profile.
Authors and Affiliations
Maulik Bhensdadia, Rakesh Vyas, Jayprakash Neema
Keywords
Related Articles
- EP ID EP213136
- DOI -
- Views 61
- Downloads 0
Assessment of Salivary Lactate Dehydrogenase Activity in Oral Squamous Cell Carcinoma
Oral cancer is a major health burden in India. Therefore, it is important and necessary to apply the vast knowledge about salivary biomarkers for screening of oral cancer. Hence, aim and objective of the study were to ev...
Case Presentations for Morbidity, Mortality at Clinical Meetings
Case Presentations for Morbidity, Mortality at Clinical Meetings
Percutaneous Sclerotherapy for the Treatment of Aneurysmal Bone Cyst, What are the Outcomes?
Aneurysmal bone cyst (ABC) shows onset in the first decades of life with incidence of 1.4/100,000 constituting about 1% of benign bone tumours. Management includes combinations of embolization, curettage with or without...
A Study of Immune Dysfunction in Patients with Breast Carcinoma
Immune system play a major role in malignant transformation and to understand the role of immune cells in breast carcinoma. We have evaluated lymphocytes, monocytes, neutrophils, ALC (absolute lymphocyte count), AMC (abs...
Parathyroid Carcinoma- A Case Report
Parathyroid carcinoma is a rare endocrine neoplasm. Although most patients present with hyperparathyroidism, it is difficult to distinguish preoperatively parathyroid carcinoma from its benign counterpart (parathyroid ad...