A Study of Immune Dysfunction in Patients with Breast Carcinoma
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2016, Vol 18, Issue 2
Abstract
Immune system play a major role in malignant transformation and to understand the role of immune cells in breast carcinoma. We have evaluated lymphocytes, monocytes, neutrophils, ALC (absolute lymphocyte count), AMC (absolute monocyte count), ANC (absolute neutrophil count), ATC (absolute T-cell count), AHTC (absolute helper T-cell count), and ACTC (absolute cytotoxic T-cell count) expression. The flowcytometry method applied for evaluation of CD markers for r e s p e c t i v e i m m u n e c e l l s i n p e r i p h e r a l b l o o d , a n d immunohistochemistry methodology applied for T-cell and neutrophils infiltration in tumor tissue of breast carcinoma patients. The median value of neutrophils (p = 0.04) and absolute count of neutrophils was found higher, while median value of lymphocytes was lower in breast carcinoma patients than healthy controls. However no difference in median value of monocytes, absolute lymphocyte counts (ALC), absolute monocyte count (AMC) was noted between these two groups. Further, median value of CD3+ T-cells and CD8+ cytotoxic T-cells was found lower and CD4+ Helper T-cells was found higher in breast carcinoma patients as compared to healthy women. In relation to clinico-pathological parameters, the median value of CD4+ helper T-cells was found significantly lower in grade III and median value of CD8+ cytotoxic T-cells was found significantly increased in BR Score 8 tumors. In tumor microenvironment, CD3+ T-cell infiltration were seen in 98% of patients. A significant higher incidence of CD3+ T-cell infiltration (2+ or 3+ score) was seen in patients with >48 years and BR Score 8 tumors. Further, patients with CD3+ T-cells infiltration in tumor microenvironment with 2+ or 3+ score had low median level of helper T-cells (CD4+) in circulation as compared to patients with 0 or 1+ score. This study observed immune suppression in breast cancer patients and antitumor activity of CD3+ T-cells in tumor microenvironment.
Authors and Affiliations
Atiya Saiyed, Birva Raiya, Hemangini Vora
Keywords
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