EXTRACTIVE SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF GABAPENTIN IN PHARMACEUTICAL DOSAGE FORMS
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2011, Vol 3, Issue 3
Abstract
Two simple, rapid, sensitive, accurate, precise and economic spectrophotometric methods have been developed for the estimation of Gabapentin (GBP) in pharmaceutical formulations. During the course of study, it was observed that acidic solution of the drug formed colored ion-association complexes with Bromocresol Green (BCG) (Method I) and Bromothymol Blue (BTB) (Method II) which were soluble in chloroform. This property of the drug was followed for the development of colorimetric methods for analysis of drug. The complex of GBP with BCG and BTB showed λmax at 416 nm and 421 nm, respectively. The linearity range for GBP was 10-120 µg ml-1 and 40-90 µg ml-1 for BCG and BTB, respectively. Recovery studies gave satisfactory results indicating that none of common additives and excipients interfere the assay method. The proposed methods are found to be simple, accurate and reproducible those were successfully applied for the analysis of pharmaceutical dosage forms.
Authors and Affiliations
Brijesh Patel, Japan Patel, Hardeep Singh, Bhagirath Patel
Keywords
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