Comprehensive Study to Decline the Burden of Skin Cancer
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2018, Vol 10, Issue 3
Abstract
Skin cancer is the most common malignancy worldwide, including malignant melanoma and Non-malignant melanoma. The progressive increase in the incidence of skin cancers is observed, mainly in cutaneous melanomas over the last few decades. UV exposure is the most common cause of skin cancer, which occurs due to mutations in the DNA of skin cells. The mutation in MAPK pathway was the main cause of the skin cancer, in which BRAF gene undergoes 75 somatic mutations. The mutation in DNA suppressed the tumor suppressor gene p53, inactivates DNA repair gene and causes mutation in proto-oncogene results in the formation of oncogene which promote the cell growth, cell proliferation and cell reproduction by affecting the process of apoptosis. Skin cancer can be prevented by healthy dietary intervention and regular physical activity. In the current review, we highlight recent global trends in the treatments of skin cancer which involve chemotherapy, radiotherapy, photodynamic therapy, biological therapy and surgery. These therapies show the effectiveness by improving the survival rate and quality of life.
Authors and Affiliations
Mamta Kumari, Madan L. Kaushik
Keywords
Related Articles
- EP ID EP618397
- DOI 10.25004/IJPSDR.2018.100302
- Views 96
- Downloads 0
ACUTE TOXICITY, IN-VITRO UROLITHIATIC & DIURETIC EVALUATION OF METHANOLIC EXTRACT OF HYGROPHILA SALICIFOLIA, WHOLE HERB IN RAT
Hygrophila salicifolia (Family: Acanthaceae) is an erect herb, nearly glabrous, mainly whole herb used as raw material in medicine. The aim of present investigation was to evaluate acute toxicity, in vitro urolithiatic a...
DESIGN DEVELOPMENT AND EVALUATION OF NANOSUSPENSION OF AZITHROMYCIN
The objective of this study is to prepare a formulation of Azithromycin which increase the oral bioavailability as well as increased solubility and dissolution rate. In the present study nine formulations were formulated...
IN VITRO STUDIES ON THE EFFECT OF PROSOPIS CINERARIA ON THE MOTILITY AND ACETYLCHOLINESTERASE OF COTYLOPHORON COTYLOPHORUM
Paramphistomosis caused by the paramphistome Cotylophoron cotylophorum constitute a major group of disease in domestic ruminants. Chemical control of helminths coupled with improved management has important worm control...
CARDIOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF CITRUS GRANDIS (L.) OSBECK PEEL ON DOXORUBICIN AND CYCLOPHOSPHAMIDE INDUCED CARDIOTOXICITY IN ALBINO RATS
The present study was designed to evaluate the cardioprotective potential of Citrus grandis (L.) Osbeck (CGO) peel extract in rats. Citrus grandis (L.) Osbeck peel extract was evaluated for protection against cyclophosph...
PRELIMINARY PHYTOCHEMICAL SCREENING AND IN VITRO ANTIOXIDANT ACTIVITY OF ETHIOPIAN INDIGENOUS MEDICINAL PLANTS, OCIMUM LAMIIFOLIUM HOCHST. EX BENTH AND OCIMUM BASILICUM L.
Antioxidants are the chemical substances which prevent the free radicals damage in the body. Numerous researches are going globally focussed on investigating natural antioxidants of plants origins. The aims of the presen...