Abstract

The main aim of this investigation is to develop fast disintegrating oral films of new moiety of coumarin by using Pectin and synthetic polymers. The coumarin moiety loaded oral-dispersible films were formulated by using HPMC , pectin, ethyl cellulose as film forming polymers. The selected polymers were natural and synthetic water soluble polymers. Generally solvent casting method was used in the manufacture of the mouth dissolving films. The formula which incorporates pectin ,HPMC , EC and also other varying ratio of solvents(DMSO, water, Ethanol) were used in the formulation of Oro-dispersible films. Citric acid was used as a salivary stimulating agent. The prepared films were subjected to the analysis of various evaluation tests such as weight variation, tensile strength, thickness, surface pH, and drug content. The significant parameters such as disintegration and dissolution profiles also studied in detail since the product was prepared for fast dissolving in the oral cavity. Based on all combinations of formulation one ideal formulation i.e, F4 is selected which acts as promising tool for systemic delivery of new moiety of coumarin.

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