Fabrication, characterization and evaluation of hepatoprotective activity drug loaded flavono nanoparticle delivery system
Journal Title: The Journal of Phytopharmacology - Year 2015, Vol 4, Issue 2
Abstract
The liver is the second largest organ is tied to almost all the bodily processes as it is responsible for filtration and biotransformation of all incoming chemicals and fluids. Liver diseases are mainly caused by toxic chemicals, excessive intake of alcohol, infections and autoimmune disorders. Hepatotoxicity due to drug appears to be a common contributing factor. Medicinal plants are significant sources of hepatoprotective drugs and more widely used than allopathic drugs as hepatoprotective because these are usually inexpensive, better cultural acceptability, improved compatibility with the human body and minimal side effects. Flavonoids are natural products widely distributed in the plant kingdom and several Flavonoids such as quercetin, rutin, silymarin reported for their hepatoprotective activities. Nanoparticles are the submicron size particles diameter of around 200nm made up of biodegradable and non-biodegradable polymers. One of the important applications of nanoparticles in medicine includes effective drug delivery system. Hence the aim of the study is to prepare single loaded Flavono polymeric nanoparticles and compare its hepatoprotective efficacy with pure drug. Flavono polymeric nanoparticles were prepared by solid dispersion method using Eutragit 100 and Sodium lauryl sulfate as a carrier and resultant nanoparticles was used for further characterization. In-vivo hepatoprotective efficacy testing was performed by ethanol induced hepatotoxicity in albino rat model evaluate the efficacy of prepared Single loaded Quercetin, Rutin and Silibinin polymeric nanoparticles in comparison with pure compound.Nanoformulation significantly elevated liver biomarker (SGPT,SGOT,ALT,ASP).The study concluded nanoparticle-assisted formulation significantly enhanced the solubility in turn it improve bioavailability in survival even toxin-induced hepatic damaged cells.
Authors and Affiliations
Senthil Kumar C, Mohan. S
Keywords
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