FABRICATION OF STOMACH SPECIFIC MUCOADHESIVE DILTIAZEM HYDROCHLORIDE TABLETS
Journal Title: Asian Journal Of Pharmaceutical Research and Development - Year 2017, Vol 5, Issue 4
Abstract
The aim of present research work was development of stomach specific mucoadhesive sustained release diltiazem hydrochloride tablet formulations for increase gastric residence with natural polysaccharides. Tablet formulations were prepared by wet granulation technique and evaluated blend by FTIR, DSC for compatibility, hardness, and friability, swelling behavior, in-vitro drug release, gastric residence and mucoadhesive strength. The formulation D5 with drugpolymer ratio 1:1 containing 16% hibiscus polysaccharide (HEC) and 13 % xanthan gum (XNG) was found to be promising for mucoadhesion and sustained release characteristics. Formulation D5 exhibited the highest efficiency of mucoadhesion strength (29.8 gm) and mucoadhesion retention in 0.1 N HCL medium even at the end of 9.3 hours when compared with other formulations. The accelerated stability studies revealed that the tablets retain their characteristics even after stressed storage conditions.
Authors and Affiliations
M. A. SHENDE,
Keywords
Related Articles
- EP ID EP303328
- DOI -
- Views 157
- Downloads 0
A BRIEF REVIEW ON FOOD ALLERGY
Food allergy is recognized as a common worldwide problem, and, like other atopic disorders, its incidence seems to increase. In the past years, investigations of allergic food proteins and related immunological responses...
A BRIEF REVIEW ON TREATMENTS OF ALZHEIMER DISEASES
Alzheimer disease is the most common form of the dementia which occurs among older people above the age of 60years. The Alzheimer’s disease once considered a rare disorder and it is now seen as a major public health prob...
Formulation and Evaluation of Orally Disintigrating Tablet of Lamotrigine
The objective of the present study was to develop orally disintegrating tablet of Lamotrigine, for treatment of epilepsy. It is also used in simple and complex partial seizures and secondary generalized tonic-clonic seiz...
PATTERN OF ADVERSE DRUG REACTIONS AND ITS MANAGEMENT IN FEMALE CANCER PATIENTS IN A PRIVATE HOSPITAL IN TELANGANA, INDIA
Chemotherapy and radiation are one of the important components of treatment for many cancers. Anti-neoplastic agents are used with caution due to their high toxicity and narrow therapeutic window. Studies describing patt...
FLUORESCENCE APPROACH TO MICELLAR SOLUBILIZATION OF AN AROMATIC COMPOUND: P-BENZOQUINONE (P-BQ)
1,4-BQ or p-BQ are ubiquitous in nature and can be synthesized by diverse strategies. Quinones are the large class of compounds endowed with rich and fascinating chemistry. A large number of chemical derivatives with p-B...