FABRICATION OF STOMACH SPECIFIC MUCOADHESIVE DILTIAZEM HYDROCHLORIDE TABLETS
Journal Title: Asian Journal Of Pharmaceutical Research and Development - Year 2017, Vol 5, Issue 4
Abstract
The aim of present research work was development of stomach specific mucoadhesive sustained release diltiazem hydrochloride tablet formulations for increase gastric residence with natural polysaccharides. Tablet formulations were prepared by wet granulation technique and evaluated blend by FTIR, DSC for compatibility, hardness, and friability, swelling behavior, in-vitro drug release, gastric residence and mucoadhesive strength. The formulation D5 with drugpolymer ratio 1:1 containing 16% hibiscus polysaccharide (HEC) and 13 % xanthan gum (XNG) was found to be promising for mucoadhesion and sustained release characteristics. Formulation D5 exhibited the highest efficiency of mucoadhesion strength (29.8 gm) and mucoadhesion retention in 0.1 N HCL medium even at the end of 9.3 hours when compared with other formulations. The accelerated stability studies revealed that the tablets retain their characteristics even after stressed storage conditions.
Authors and Affiliations
M. A. SHENDE,
Keywords
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