PATTERN OF ADVERSE DRUG REACTIONS AND ITS MANAGEMENT IN FEMALE CANCER PATIENTS IN A PRIVATE HOSPITAL IN TELANGANA, INDIA
Journal Title: Asian Journal Of Pharmaceutical Research and Development - Year 2018, Vol 6, Issue 4
Abstract
Chemotherapy and radiation are one of the important components of treatment for many cancers. Anti-neoplastic agents are used with caution due to their high toxicity and narrow therapeutic window. Studies describing pattern of adverse drug reactions in cancer chemotherapy and radiation therapy patients are less in India. This study aims to evaluate the pattern of ADR‟s due to cancer chemotherapy and radiation therapy in hospitalized patients and to assess the causality and severity of these reactions in Telangana state, India. This was a prospective observational study conducted in a private hospital in Telanganaregion from January to august. Two thousand three hundred and forty two ADR‟s were recorded from 254 patients. Most common ADR‟s were vomiting (10.7 %), nausea (10.7 %) and fatigue (10.7 %). Majority of the ADR‟s (53.5 %) were affecting the Gastro-intestinal system. Naranjo scale for causality assessment showed 54.3 % of the reaction to be “definite”, 36.8 % to be “probable”. Modified Hartwig and Siegel scale for severity showed most reaction (84.1 %) to be of “moderate level”, while 13.3 % of reactions were of “mild level”. There is an immediate need to create awareness among health care professionals regarding the importance of the pharmacovigilance system. Use of preventive measures is to be enhanced in order to reduce the incidence and severity of ADR‟s. This study showed most ADR‟s are preventable with effective ADR monitoring.
Authors and Affiliations
Kishore P, Meghana G
Keywords
Related Articles
- EP ID EP499517
- DOI 10.22270/ajprd.v6i4.381
- Views 116
- Downloads 0
REGULATORY ASPECTS OF CLEANING AND CLEANING VALIDATION IN ACTIVE PHARMACEUTICAL INGREDIENTS
Pharmaceutical product and active pharmaceutical ingredients (APIs) can be contaminated by other pharmaceutical products or APIs, by cleaning agents, by microorganisms or by other materials e.g....
RESEALED ERYTHROCYTE DRUG DELIVERY SYSTEM
Erythrocytes, the most abundant cells in the human body, have potential carrier capabilities for the delivery of drugs. New drug delivery systems have been developed to overcome the limitations associated with the conven...
KNOWLEDGE AND PRESCRIBING PRACTICE OF AMBULATORY CARE PHYSICIANS ABOUT DISTINCT ANTIBIOTICS TOWARDS TRIVIAL RESPIRATORY TRACT INFECTED PATIENTS: STRATEGIES FOR OPTIMAL OUTCOMES AND MINIMIZED RESISTANCE
According to World Health Organization (WHO), respiratory tract infections kill 2.6 million children every year worldwide so, it is recognized as the leading cause of morbidity and mortality. Respiratory tract diseases a...
DEVELOPMENT AND CHARACTERIZATION OF FENOFIBRATE TABLET BY COMPARING TWO DIFFERENT SOLUBILITY AND DISSOLUTION ENHANCEMENT METHODS
Fenofibrate is a drug included in BCS class II category, generally used to reduce cholesterol level in patient having a risk of cardiovascular disease. The main aim of this research was to ameliorate solubility...
A REVIEW: MICROSPONGE-AN EFFECTIVE DRUG DELIVERY SYSTEM
Microsponge Delivery System (MDS) is a unique technology for controlled delivery of drug. MDS technology has been introduced in topical drug products to facilitate the controlled release of active drug into the skin in o...