Fabrication of titanium based biphasic scaffold using selective laser melting and collagen immersion
Journal Title: International Journal of Bioprinting - Year 2017, Vol 3, Issue 1
Abstract
Tissue engineering approaches have been adopted to address challenges in osteochondral tissue regeneration. Single phase scaffolds, which consist of only one single material throughout the whole structure, have been used extensively in these tissue engineering approaches. However, a single phase scaffold is insufficient in providing all the properties required for regeneration and repair of osteochondral defects. Biphasic scaffolds with two distinct phases of titanium/type 1 collagen and titanium-tantalum/type 1 collagen were developed for the first time using selective laser melting and collagen infiltration. Observation of the biphasic scaffolds demonstrated continuous interface between the two phases and mechanical characterization of the metallic scaffolds support the feasibility of the newly developed scaffolds for tissue engineering in osteochondral defects.
Authors and Affiliations
Swee Leong Sing, Shuai Wang, Shweta Agarwala, Florencia Edith Wiria, Thi Mai Hoa Ha and Wai Yee Yeong
Keywords
Related Articles
- EP ID EP678662
- DOI -
- Views 139
- Downloads 0
Coaxial nozzle-assisted electrohydrodynamic printing for microscale 3D cell-laden constructs
Cell printing has found wide applications in biomedical fields due to its unique capability in fabricating living tissue constructs with precise control over cell arrangements. However, it is still challenging to print c...
A perspective on 4D bioprinting
3D bioprinting has been invented for more than a decade. A disruptive progress is still lacking for the field to significantly move forward. Recently, the invention of 4D printing technology may point a way and hence the...
Creation of a vascular system for organ manufacturing
The creation of a vascular system is considered to be the main object for complex organ manufacturing. In this short review, we demonstrate two approaches to generate a branched vascular system which can be printed using...
A novel bioactive PEEK/HA composite with controlled 3D interconnected HA network
Polyetheretherketone (PEEK) is a high-performance thermoplastic biomaterial which is currently used in a variety of biomedical orthopaedic applications. It has comparable tensile and compressive strength to cortical bone...
3D bioprinting for tissue engineering: Stem cells in hydrogels
Surgical limitations require alternative methods of repairing and replacing diseased and damaged tissue. Regenerative medicine is a growing area of research with engineered tissues already being used successfully in pati...