Facile Synthesis and Characterization ofBiodegradable Calcium alginate nanoparticles
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 15, Issue 3
Abstract
Alginate is one of the most abundant natural marine polysaccharides which is an attrac-tive source of materials for the formulation of biodegradable nanoparticle delivery systems. In this study, calcium alginate nanoparticles (CALNPs) were successfully synthesized without the use of harmful organic solvents or very high temperatures. The resulting Nano emulsion of the nanoparticles showed no microbial contamination and were easily degraded when exposed to the natural environment. The empty CALNPs were bigger than those which con-tained either Vitamin E or Vitamin D3. The CALNPs all recorded a negative zeta potential which may serve as an indicator of long-term stability. Alginate is one of the most abundant natural marine polysaccharides [1] which is an attractive source of materials for the formulation of biodegradable nanoparticle delivery systems. Various characteristics including biocompatibility, non-toxicity, biodegradability, and low cost make it a suitable candidate for biomedical applications [2-6]. Alginate or alginic acid, is an anionic polysaccharide that contains ma homopolymeric blocks of (1,4)-linked -D-mannuronate (M) unit and L- guluronate (G).
Authors and Affiliations
Enayah Alhashim, Jackson Lay Jr, Zoraida P Aguilar
Keywords
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- EP ID EP587663
- DOI 10.26717/BJSTR.2019.15.002718
- Views 159
- Downloads 0
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