Factors Associated with a Low CD4 Count among HIV-1 Infected Patients at Enrolment into HAART in Jos, Nigeria
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 13
Abstract
Aim: To determine the factors associated with a low CD4 count among HIV-1 positive patients. Study Design: Cross-sectional study. Place and Duration of Study: Adult HIV clinic at the Jos University Teaching Hospital, Jos, between October 2010 and April 2011. Methodology: Data on demographic, clinical and laboratory variables for 218 HIV-1 infected patients aged 20 years and older were analysed. A low CD4 cell count was defined as CD4 cell count <200 cells/ml based on the WHO criteria for severe immune suppression. A multivariate logistic regression modeling was fitted to determine the variables that were independently associated with a low CD4 count. Results: Of the 218 HIV-1 infected patients, 119 (54.6%) had a low CD4 count at enrolment. The odds of having a low CD4 count was: 7 times higher in patients with WHO clinical stage 3 or 4 compared to those with stage 1 or 2 (P<.001) and 4 times higher in those with HIV RNA viral load ≥4.6 log10 copies/ml compared to those with less (P<.001); but the odds of having a low CD4 count was reduced by 63% in those patients that were resident in Plateau State compared to those resident outside the state (P=.01). Conclusion: Our study patients were more likely to have a CD4 count <200 cells/ml which would suggest late presentation/ late HIV diagnosis and thus a delayed opportunity for timely access to HIV care and initiation of antiretroviral therapy. There is the need to intensify efforts in early routine HIV counseling and testing not only in health facilities in the cities but also in smaller towns and rural communities, so as to reduce the frequency of late HIV diagnosis with its potential implications.
Authors and Affiliations
Augustine O. Ebonyi, Oche O. Agbaji, Joseph A. Anejo-Okopi, Stephen Oguche, Patricia A. Agaba, Solomon A. Sagay, Prosper Okonkwo
Keywords
Related Articles
- EP ID EP349123
- DOI 10.9734/BJMMR/2014/8469
- Views 59
- Downloads 0
Association between Interleukin 6 Gene Polymorphism and Human Papilloma Virus Infection in Oral Squamous Cell Carcinoma Patients
Aims: To find out an association between Human Papilloma Virus and IL 6 gene polymorphism in Oral Squamous Cell Carcinoma patients. Study Design: Cross-sectional study. Place and Duration of Study: Ziauddin Hospital (De...
Neuroprotective Role of Green Tea Polyphenols on the Superior Colliculus in MPTP Mice Model of Parkinson’s Disease
Aim: This study investigated the neuroprotective role of green tea polyphenols on the superior colliculus of MPTP mice model of Parkinson’s disease. Study Design: Twenty-five adult male mice (Mus musculus) weighing betwe...
Amniotic Membrane Transplantation: A Good Treatment Option for Refractory Neurotrophic Keratitis
Neurotrophic keratitis is a degenerative disease of the corneal epithelium resulting from impaired corneal innervation, possibly leading to perforation. In this report, we present a case with a history of herpetic kerati...
A Simple System to Predict Mortality in Medical Intensive Care Unit
Background: Advances in critical care have increased survival chances and the demand for a scientific approach to outcome prediction. The present study aimed to investigate the associations of clinical information, demog...
Canine Parvovirus-based Immunotherapy in Breast Cancer Patients, as Coadjuvant Treatment to Surgery Management: 9 Years Survival Following
Background: Breast Cancer continues to be a major oncological problem. Despite the several advances in medical science focusing on controlling this condition and avoiding relapse, is inevitable. The relapse rates with co...