Neuroprotective Role of Green Tea Polyphenols on the Superior Colliculus in MPTP Mice Model of Parkinson’s Disease
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 21, Issue 6
Abstract
Aim: This study investigated the neuroprotective role of green tea polyphenols on the superior colliculus of MPTP mice model of Parkinson’s disease. Study Design: Twenty-five adult male mice (Mus musculus) weighing between 20-30 grams were used for this study. The mice were randomly placed into five groups of five mice each: A (Control; mice pellets), B (MPTP 10mg/kg, IP), C (MPTP + GT; 300 mg/kg GT orally), D (GT + MPTP), E (GT; 300 mg/kg). Place and Duration of the Study: Department of Anatomy, Babcock University. Between February and May 2016. Methodology: The brains were removed weighed and the midbrain excised processed histology and stained routinely with H&E and silver stains. Results: The results showed significant (P<0.005) reduction in the relative brain to body weight and neuronal density in the superior colliculus; characterized by neuronal atrophy as signaled by vacuolations and pyknosis in the MPTP and green tea only groups. Whereas pre-treatment with green tea polyphenol resulted in significant (P<0.005) increase in the relative brain to body weight and increase in the superior colliculus neuronal density when compared with the MPTP and green tea only groups. Conclusion: From our results we can conclude that pre-treatment with green tea polyphenols confers greater protection on the superior colliculus in MPTP mice model of Parkinson’s disease.
Authors and Affiliations
Philemon Dauda Shallie, Kanyinsola A. Koya, Oluwadamilola Faith Shallie, Adedayo D. Adekomi
Keywords
Related Articles
- EP ID EP311774
- DOI 10.9734/BJMMR/2017/33329
- Views 66
- Downloads 0
The Effect of Lithium Disilicate Glass-Ceramic Core Thickness on Fracture Thickness of All-ceramic Restorations
Statement of the Problem: Fracture strength is fundamental for the long-term success and clinical service of all-ceramic restorations. Core thickness is an important factor affecting fracture strength. Purpose: The main...
Ease of Intubation with the McGRATH® MAC, C-MAC® or Macintosh Laryngoscopes by Novice Operators in Simulated Difficult Airways – A Manikin Study
A variety of video laryngoscopes have been introduced to facilitate endotracheal intubations as failed intubations can result in morbidity and mortality. We aimed to compare the use of the conventional Macintosh laryngos...
Factors Influencing A & E Attendance, Admissions and Waiting Times at Two London Hospitals
Aims: To inform wider debate regard attendance at the Accident & Emergency department via analysis of the complex factors regulating attendances at two London hospitals. Study Design: Analysis of 508,569 A&E attendances...
Prevalence and Determinants of Poor Sleep Quality among Myanmar Migrant Workers in Malaysia: A Cross-sectional Study
Background: Sleep quality is an important determinant of health; so much so that the socio-economic and healthcare burden of poor sleep quality is alarming. In Malaysia, there is a shortage of sleep-quality studies condu...
Comparative Study between Effect of Simvastatin (5 mg/Kg) and Simvastatin (50 mg/Kg) in an Early Treatment of Experimentally Induced Colitis in Mice
Inflammatory bowel disease (IBD) (ulcerative colitis and Crohn's disease) is a chronic intestinal inflammatory disease characterized by tissue edema, increased gut epithelial permeability, and extensive infiltration of t...