Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women
Journal Title: The Medical Bulletin of Haseki - Year 2020, Vol 58, Issue 1
Abstract
Aim: To assess the risk factors associated with high rate of insufficient endometrial sampling on endometrial biopsy in postmenopausal women. Methods: Data were retrieved from the records of 522 consecutive patients who underwent endometrial sampling. Logistic regression analyses were performed to determine various factors associated with scanty endometrial biopsy. The exclusion criteria included patient refusal, uncertain menopausal status, cervical carcinoma detected after sampling and unavailable records. Results: The sample was insufficient for a definitive diagnosis in 143 (25.9%) patients. Out of these, 53 cases were investigated with invasive procedures. Further histopathological examination revealed that five (9.4%) patients had uterine malignancy. Based on the multivariate analysis, time since the onset of menopause [Odds ratio (OR)=1.044, 95% confidence interval (CI)=1.000-1.090, p=0.049] was significantly associated with insufficient endometrial biopsy in cases with a endometrial thickness of >12 mm on ultrasonography (OR=0.624, 95% CI=0.472-0.824, p=0.001). The use of dilation and curettage technique (OR=0.662, 95% CI=0.522-0.841, p=0.001) decreased the risk of insufficient sampling on endometrial biopsy. Conclusion: Time since the onset of menopause and the thickness of endometrium were significant independent factors associated with insufficient sample. Using Karman cannula for endometrial aspiration may not be a reliable method in the evaluation of postmenopausal women. An insufficient endometrial sample does not rule out endometrial carcinoma, therefore, a further histopathological examination is recommended.
Authors and Affiliations
Seda Ateş, Ayşe Filiz Gökmen Karasu, Halime Çalı, Zeynep Soyman, Ömer Uysal
Keywords
Related Articles
- EP ID EP685258
- DOI 10.4274/haseki.galenos.2019.5584
- Views 143
- Downloads 0
Effects of Inappropriate Acetylsalicylic Acid Use on Non-fatal Bleedings
Aim: This study aims to assess of using asetylsalicyclic acid (ASA) on non-fatal major and minor bleeding events in patients with inappropriate, primary and secondary prevention groups. Methods: Nine thousand, six hundr...
Mini-open Versus Arthroscopic Rotator Cuff Repair: A Comparison of Clinical Results and Re-tear Rates by Magnetic Resonance Arthrogram
Aim: The aim of this study was to compare the re-tear rates and clinical results between mini-open and full arthroscopic techniques of the rotator cuff repair. Methods: We retrospectively reviewed a total of 82 patients...
Endoscopic Retrograde Cholangiopancreatography Related Bleeding Complication and Easy Management
Aim: Endoscopic retrograde cholangiopancreatography (ERCP) has serious complications such as pancreatitis, perforation, cholangitis and bleeding. Our aim is to raise awareness about bleeding complication and management a...
Foreign Bodies on the Path of Nutrition: Retrospective Evaluation of Our Clinical Experience
Aim: Swallowing foreign bodies is a common clinical problem. Especially sharp and pointed objects can cause life-threatening complications such as obstruction, gastrointestinal (GI) bleeding or intestinal perforation. In...
Predictive Factors Affecting Axillary Lymph Node Metastasis in Breast Cancer
Aim: The status of axillary lymph node metastasis (ALNM) at diagnosis has been considered as one of the most important prognostic factors for overall and disease-free survival in patients with breast cancer. Determinatio...