Predictive Factors Affecting Axillary Lymph Node Metastasis in Breast Cancer
Journal Title: The Medical Bulletin of Haseki - Year 2019, Vol 57, Issue 4
Abstract
Aim: The status of axillary lymph node metastasis (ALNM) at diagnosis has been considered as one of the most important prognostic factors for overall and disease-free survival in patients with breast cancer. Determination of breast cancer patients at risk for ALNM is important for treatment planning. The purpose of this study was to determine the factors that affect axillary lymph node involvement in breast cancer in addition to biological and pathological parameters to prevent unnecessary lymph node dissections. Methods: Immunohistochemical and pathologic features of 131 breast cancer patients, who underwent breast surgery, were investigated retrospectively. Results: ALNM was detected in 60% (n=79) of patients. In univariate analysis, histological grade, tumor size, lymphovascular invasion, perineural invasion, HER2 positivity and large intraductal component were found to be high risk factors for ALNM. In multivariate analysis, increased tumor size (T1; OR: 0.2, p<0.034) and presence of lymphovascular invasion (OR: 0.2, p<0.001) were found to be independent factors for ALNM. Conclusion: In our study, presence of lymphovascular invasion and increased tumor size were found to be independent predictive factors for axillary lymph node involvement. In univariate analysis, histological grade, tumor size, lymphovascular invasion, perineural invasion, HER2 positivity and large intraductal component were found to be high risk factors for ALNM. Patients carrying these factors may be included in the higher risk group for lymph node involvement. However, more data is needed to identify the factors that may help to decide for axillary lymph node dissection.
Authors and Affiliations
Suat Benek, Cihad Tatar
The Difference of Thyroid Cancer in Hyperactive Adenoma and Hyperthyroidism in Endemic Areas
Aim: In recent years, dramatic changes in treatment approaches and conflicting publications on thyroid cancer have been reported from endemic regions. The probability of cancer has increased in endemic areas especially i...
Is Facet Tropism an Acquired Status or is It Related with Age? MRI Study
Aim: We aimed to reveal the facet joint orientation and tropism and their relationship with age in patients without degenerative spine disease in lumbar magnetic resonance imaging (MRI) examinations. Methods: After obta...
Impact of Admission, Fasting Glucose and HbA1c Levels on in-stent Restenosis in The Patients Treated with Primary Percutaneous Coronary Intervention in 5-Year Follow-up
Aim: Despite advances in-stent technology, in-stent restenosis (ISR) is still a major problem following percutaneous coronary intervention (PCI) and its reasons have not been fully revealed. In the presented study, we in...
Is Complement Factor H Tyr402His Variant a Potential Cause of Ankylosing Spondylitis?
Aim: Ankylosing spondylitis (AS) is an autoimmune disease caused by chronic inflammatory response. Complement system is the major component of the innate immune defence. In this study, we investigated the potential assoc...
The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development
Aim: Primary dysmenorrhea (PD) is among the most common gynecological diseases in young women presenting to emergency department. It has been shown that cytokines played roles in PD pathogenesis. Interleukin-4 (IL-4), a...