Familial Mediterranean fever with Prolonged Febrile Myalgias Syndrome: Clinical, Laboratory and Demographic Characteristics of 9 Patients
Journal Title: JOURNAL OF CONTEMPORARY MEDICINE - Year 2018, Vol 8, Issue 3
Abstract
Objective: The aim of this study is to retrospectively review a group of patients with prolonged febrile myalgias syndrome in patients with FMF and to share their clinical experience.Materials and Methods: Nine patients with prolonged febrile myalgias syndrome were identified from the electronic database of a Selçuk University Medical Faculty Pediatric Emergency Department and Pediatric Rheumatology Polyclinic (September 2016-May 2018). Their clinical and laboratory data were collected. Data such as age, sex, accompanying symptoms of FMF, previous follow-up of FMF, duration of follow-up after diagnosis, hospital stay, number of days before symptoms, complete blood count and acute phase reactants were recorded. Pulse corticosteroid therapy was administered at a dose of 10mg/kg.Results In the study, 7 of 9 patients (77.8%) were females and 2 (22.2%) were male. The ages of our patients ranged from 39 months to 192 months and the mean median was 145 months. Only 2 (22.2%) of the patients had previously been diagnosed and received colchicine treatment. The first sign of FMF in 7 of patients (77.78%) was PFMS. When genetic analysis of the patients was examined, M694V homozygous was detected in 4 patients (44.44%). Acute phase reactors were at high level in all patients. Creatine kinase levels were within normal limits in all patients. The patients received intravenous methylprednisolone. In all patients, complete recovery was seen after treatment. Conclusion: PFMS should be considered in the presence of high fever, acute phase reactant height, and long-standing myalgia that does not meet FMF criteria.
Authors and Affiliations
Alaaddin Yorulmaz, Hikmet Akbulut, Şükrü Arslan
Keywords
Related Articles
- EP ID EP423522
- DOI 10.16899/gopctd.456887
- Views 105
- Downloads 0
A Rare Complication in the ICU: Missed Central Venous Guide Wire
Percutaneous central venous catheterization (CVC) is an essential part of the care in the ICU, emergency department, and operating theater. Guidewires are routinely used in the Seldinger technique during central venous c...
Çölyak hastalığı tanısı ile izlenen çocuklarda klinik özellikler: tek merkez sonuçları
Amaç: Çölyak hastalığı, genetik olarak duyarlı bireylerde glütenin beslenme ile alınması sonucunda ortaya çıkan immun aracılı bir sistemik bozukluktur. Glütensiz diyet, tedavinin temelini oluşturmaktadır. Çalışmamızda, ç...
17 Yaşında Kız Hastada Feokromasitoma Eksizyonu İçin Uygulanan Anestezi Yönetimi: Olgu Sunumu
Kromafin dokularının nadir bir tümörü olan feokromasitoma yüksek miktarda katekolamin salgılanmasıyla karakterizedir. Bu tümörlerin sadece %5’i çocuk populasyonunda tanımlanmıştır. Bu makalede feokromasitomanın yanında A...
Low plasminogen activator inhibitor-1 levels in thyroid carcinoma: uPA/PAI-1 paradox in cancer proggression
Aim: Plasminogen activator inhibitor-1 (PAI-1) potently inhibits cell migration and apoptosis. Increased levels of PAI-1 were demonstrated in a great variety of cancers. Many studies demonstrated increased expression of...
Evaluation of Perception and Practice Model of Spiritual Care in Intern Nursing and Midwifery Students
Aim: Evaluation of Perception and Practice Model of Spiritual Care in Intern Nursing and Midwifery Students.Methods: This descriptive study was conducted at Aydın School of Health Adnan Menderes University on nursing and...