FAST DISSOLVING TABLETS OF ACECLOFENAC: DEVELOPMENT AND OPTIMIZATION
Journal Title: Innoriginal: International Journal Of Sciences - Year 2018, Vol 5, Issue 3
Abstract
Objective: The present research works was aimed to develope and optimize fast dissolving tablets of aceclofenac via 32 full factorial designs to investigate the influence of formulation variables. Methods: Different concentration of crospovidone and mannitol were selected as independent variables. Wetting time and disintegration time were selected as dependent variables. The optimized tablets were then evaluated for various parameters like hardness, friability, disintegration time wetting time. Result and conclusion: The results of multiple linear regression analysis revealed that for obtaining a rapidly disintegrating dosage form, tablets should be prepared using optimum concentration of crospovidone and mannitol.
Authors and Affiliations
SHIVALI SINGLA, SUPRIYA SHARMA, SURESH PUROHIT, HIMANSHU PALIWAL, SACHIN GOYAL
Keywords
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